Binding evolutionary conservation

Annexins form an evolutionary conserved family of Ca2+ and phospholipid binding proteins implicated in membrane trafficking and the regulation of Ca2+ currents across membranes. 

Lichtarge O, Bourne HR, Cohen FE (1996) Evolutionary conserved G (alpha beta gamma) binding surfaces support a model of die G protein-receptor complex. Proc. Natl. Acad. Sci. USA 93(15) 7507-7511... 

Key Words Multiple alignment alignment tool evolutionary conservation conserved elements conserved transcription factor binding sites. 

Cytochrome c oxidase is a highly conserved enzyme the three core subunits (I, II and III) encoded by the mitochondrial genome in eukaryotes has high amino acid sequence homology with prokaryotic and eukaryotic species. Detailed analysis of evolutionary conservation of lipid-binding sites in cytochrome c oxidase (Qin et al., 2007) shows that lipid binding sites are specific and... 

Because the complement system is an evolutionary conserved protein cascade, the observed host specificity of bacterial complement inhibitors is very striking. The Gram-positive proteins SAK, SCIN and ScpB and the Neisserial porin molecules display strict human specificity. In case of Neisserial porin which exclusively binds human C4BP, host-spedfidty of the complement inhibitor bindii may contribute to host specificity of the infection. Understandii the basis for species specificity of complement evasion will hopefully lead to development of better animal models for infectious diseases, for example, creating transgenic mice for human complement inhibitory proteins to study pathc ens such as N. gonorrhoeae. 

Evolutionary conservation of mannan-binding lectin (MBL) in bony fish identification, characterization and expression analysis of three bona fide coUectin homologues of MBL in the rainbow trout (Onchorhynchus mykiss) ,Fish Shellfish... 

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