Bicyclic Fused Heterocycles

Incorporation of the 2-aryl-2-methylacetic acid moiety characteristic of NSAID s as part of 

The majority of endogenous prostaglandins tend to exert undesirable effects on the cardiovascular system. These compounds as a rule tend to cause vasoconstriction and promote platelet aggrega- 

The derivative from an isomeric fused system has been described as a sedative-hypnotic compound. The synthesis starts by condensation of the aminopicoline 32 with the haloketone 33. The resulting pyrrolo[l,2-a]pyridine 34 then undergoes a Mannich reaction with formaldehyde and dimethylamine to give the aminomethylated derivative 35. After quatemization of the di-methylamino group in 35 with methyl iodide, the ammonium group is displaced by cyanide to 

The narrow therapeutic range of digitalis related cardiotonic agents has resulted in an extensive effort to identify compounds in other structural classes which will improve cardiac function. The discovery of the heterocyclic cardiotonic drug, amrinone, led to research on other heterocyclic compounds for that indication. The imidazopyridine, isomazole (57), is representa- 

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