Beryllium disease susceptibility

Newman LS and Kotzin BL (2000) Beryllium presentation to CD4-E Tcells underlies disease susceptibility HLA-DP alleles in chronic beryllium disease. Proc Natl Acad Sd USA 97 12717-12722. 

Lombardi G, Germain C, Ueen J, Fioeillo MT, Du Bois RM, Jones-Williams W, Saltini C, Soeeentino R and Lechlee R (2001) HLA-DP allele-specific T cell responses to beryllium account for DP-associated susceptibility to chronic beryllium disease. J Immunol 166 3549-3555. 

Wang Z, White PS, Petrovig M, Tatum OL, Newman LS, Maier LA and Marrone BL (1999) Differential susceptibilities to chronic beryllium disease contributed by different Glu69 HLA-DPBl and -DPAl alleles. ] Immunol 163 1647-1653. 

Maier LA, McGrath DS, Sato H, et al. Influence of MHC class II in susceptibility to beryllium sensitization and chronic beryllium disease. J Immunol 2003 171(12) 6910-6918. 

Weston A, Ensey J, Kreiss K, et al. Racial differences in prevalence of a suprat3fpic HLA-genetic marker immaterial to pre-employment testing for susceptibility to chronic beryllium disease. Am J Ind Med 2002 41(6) 457 65. 

Individuals whose jobs expose them to unusually high particulate concentrations are especially susceptible to health problems from the pollutant. For example, men and women who work with the mineral asbestos are very prone to development of a serious and usually fatal condition known as asbestosis, in which fibers of the mineral become embedded in the interstices (the empty spaces within tissue) of the lung. Similar conditions are observed among coal workers who inhale coal dust (pneumoconiosis, or black lung disease) textile workers (byssinosis, or brown lung disease) those who work with clay, brick, silica, glass, and other ceramic materials (silicosis) and workers exposed to high levels of beryllium fumes (berylliosis). 

Fontenot AP, Maier LA. Genetic susceptibility and immune-mediated destruction in beryllium-induced disease. Trends Immunol 2005 26(10) 543-549. 

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