Bergmann glial cells

These contain GluR-B, GluR-C and GluR-D transcripts (Sato et al., 1993). 

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Grosche, J., Matyash, V., Moller, T. etal. Microdomains for neuron-glia interaction parallel fiber signaling to Bergmann glial cells. Nat. Neurosci. 2 139-143,1999. 

Grosche, J., Kettenmann, H., and Reichenbach, A. (2002). Bergmann glial cells form distinct morphological structures to interact with cerebellar neurons.. Neurosci. Res. 68, 138—149. 

Physiology of Bergmann Glial Cells Thomas Muller and Helmut Kettenmann... 

Kettenmann H, Filippov V (2002) Signaling between neurones and Bergmann glial cells, hr The Tripartite Synapse Gha in Synaptic Transmission (VolteiTa A, Magistretti PJ, Haydon PG, eds). New York Oxford University Press, pp 139—150. 

Muller T, Moller T, Berger T, Schnitzer J, Kettenmann H (1992b) Calcium channel entry through kainate receptors and resulting potassium channel blockade in Bergmann glial cells. Science 256 1563-1566. 

Muller T, Grosche J, Ohiemeyer C, Kettenmann H (1993) NMDA-activated currents in Bergmann glial cells. Neurorepoa 4 671-674. 

Bergles DE, Dzubay JA, Jahr CE (1997) Glutamate transporter currents in Bergmann glial cells follow the time course of extrasynaptic glutamate. Proc Natl Acad Sci USA 94 14821-14825. 

Fig. 9. Purkinje cell in sagittal section. Haggqvist stain. A. The small, densely stained nuclei in the Purkinje cell layer belong to the Bergmann glial cells. B. Initial segment of Purkinje cell myelinated axon (A) surrounded by pinceau of terminal basket cell axons. Abbreviations A = Purkinje cell axon B = Bergmann glial fiber D = Purkinje cell dendrite. Bar = 25 g.m.

Fig. 47. Sagittal sections of the rat cerebellar cortex immuno-labelled with antibodies to GluRl (a), GluR2/3 (b,e), and GluR4 (c,d). As, astrocyte-like cells BG, Bergmann glial processes Go, Golgi cell Gr, granular layer L, Lugaro cell Mo, molecular layer Pj, Purkinje cell body WM, white matter small arrow, Purkinje cell dendrite asterisks, Bergmann glial cell body arrow head, basket/ stellate cell. Petralia and Wenthold (1992).

Fig. 48. Electron micrograph of the synaptic distribution of immunoreactivity for the GluRl subunit of the AMPA receptor in rat cerebellum as detected by an antibody against the carboxy-terminal (intracellular) region of GluRl. A. A spine (s) emerging from a Purkinje cell dendrite (Pd) establishes an immunopositive type 1 synapse (solid arrows) with a parallel fiber terminal (pft). Intra-cellular immunoreactivity is present inside Bergmann glial cell processes along dendritic elements (e.g., open arrow). B. The peroxidase reaction end-product labels the postsynaptic density (psd) at the intracellular face of the postsynaptic membrane (pom) and not the synaptic cleft between the presyaptic (pem) and postsynaptic (pom) membranes. Scale bars in A = 0.5 /xm, in B = 0.1 jum. Baude et al. (1994).

Fig. 94. A and B. Distribution of 3-fucosyl-N-acetyl-lactosamine (FAL)-immunoreactive Bergmann glial cells in adult mouse cerebellum. Note zonal distribution of immunoreactive neuroglia in molecular layer (MOL) in A. GCL, granular layer. Bars in A = 800 /tm, in B = 100 /jm. Courtesy of Dr. J.K. Mai, Department of Neuro-anatomy, Heinrich Heine University, Diisseldorf.

Several substances are distributed in zonally distributed Bergmann glial cells. This may be the case for 5 -N, and has been observed for 3-fucosyl-acetyl-lactosamine (FAL) immunoreactivity in mouse cerebellum (Fig. 94) (Bartsch and Mai, 1991 Marani and Mai, 1992). 

The protein kinase types a, ySll, j and C have been localized in Bergmann glia (Shimohama et al., 1990 Hidaka et al., 1988 Wetsel et al., 1992). Bergmann glial cells... 

Somogyi P, Eshhar N, Teichberg VI, Roberts JDB (1990) Subcellular localization of a putative kainate receptor in Bergmann glial cells using a monoclonal antibody in the chick and fish cerebellar cortex. 

Suarez I, Bodega G, Arilla E, et al. 1992. Different response of astrocytes and Bergmann glial cells to portacaval shung. An immunohistochemical study in the rat cerebellum. Glia 6 172-179. 

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