Benzylcyanide

Nitro derivatives Benzylcyanide + benzyl- trimethylammonium hydroxide Nitro compoimds, e.g. explosives, or pesticides containing nitro groups yield gray to bluish-green chromatogram zones on a brownish backgroimd. [30]... 

In most other cases the relationship will allow the approximate prediction of the half-wave potentials of a given ion in a solvent of given donicity by interpolation. It may be expected that E jy2 for a certain metal ion in tetramethylene sulfone (DN = 14.8) will be similar to that in PDC (DN = 15.1), benzylcyanide (DN = 15.1) or ethylene sulfite (DN = 15.3). Likewise, the half-wave potentials are expected to be similar in nitrobenzene (DN = 4.4) and nitromethane (DN = 2.7). In an analogous manner the half-wave potentials may be predicted in methyl acetate, diethylether, pyridine, and various other solvents. 

In addition to the simultaneous impact of an odor mixture, differential evaporation may alter the signal over time, indicating the age of a scent. As an example, the major component of the chest gland secretion of the thick-tailed galago. Galago crassicaudatus, is benzylcyanide. It evaporates rapidly and is present for only about 1 hour. The other two identified compounds last for several days. In a behavioral corollary, galagos retreat from a scent mark that is less than 1 hour old, while older marks have no such effect (Katsir and Crewe, 1980). 

Disopyramide Disopyramide, a-(2-diisopropylaminoethyl)-a-phenyl-2-pyridineacetamide (18.1.6), is synthesized by arylating benzylcyanide with 2-chloropiridine in the presence of sodium amide and subsequent alkylation of the resulting a-phenyl-a-(2-pyridyl) acetonitrile... 

Chemically, calcium channel blockers are synthesized up of a fairly diverse group of compounds, which testifies of the diverse receptive regions both on the cell membrane surface as well as within the cell. Verapamil, which can be viewed as a benzylcyanide derivative, is one of the oldest and most actively used compounds of this class up to the present day. Diltiazem is a thiodiazepine, while nifedipin and nicardipine are derivatives of dihydropyridine. 

The interaction of ethyl diazoacetate with benzylcyanides (293) opened a straightforward way to aminopyrazoles (295) (84FES618), probably via azo intermediates 294 (Scheme 74). 

Benzylcyanid, Phenylacetonitril or Phenytessig-saure-nitril in Ger), C6HS.CH2.CN mw 117.14,... 

From benzylcyanide and deoxybenzoin alkyl derivatives can be formed by tho action of sodium and alkyl halides ... 

Trifluoromethyl-a-(p-toluenesulfonyloxyimino)benzylcyanide Methyl thioglycolate Triethylamine Potassium hydroxide... 

To a stirred solution of 3-trifluoromethyl-a-(p-toluenesulfonyloxyimino) benzylcyanide in methanol containing methyl thioglycolate was added dropwise over a 30 min period triethylamine. The reaction mixture was stirred at room temperature for 4 h following complete addition, and then was cooled to 0°C and filtered. The precipitate which was collected was recrystallized from hexane and ethyl acetate to provide methyl 3-(3-trifluoromethylphenyl)-4-amino-5-isothiazolecarboxylate, melting point 94°-95°C. 

Chloro-9-phenylpurine reacts with a variety of nucleophiles including 0-alkyl, 0-aryl, SR, and NHR to produce the 2-substituted purines. The compound also reacts with benzylcyanide and ethyl cyanoacetate to give the corresponding purine-2-CHR(CN) derivative but failed to react with other active methylene derivatives, ketones, or potassium cyanide. In contrast, 9-phenyl-2-methyl-sulfonylpurine reacted readily with active methylene compounds, ketones, and potassium cyanide <87CPB4972>. 

In general, substrate affinity and cyanide release increase with increasing size of the R group with benzylcyanide having a Km as low as 2.3 pM for rat nasal micro-somes. Metabolism of acrylonitrile may proceed via an epoxide, formed by CYP, which is then converted to the diol by epoxide hydrolase. The diol would then release cyanide by the same mechanism as other cyanohydrins. 

The phenyl acetic acid esters are highly valuable intermediates for a lot of applications. Among them, they are applied for the synthesis of fragrances e.g. ethyl ester (honey odour), isobutyl ester (sweet roses odour). The present industrial process for phenyl acetic esters starts from benzylchloride and uses the reactions with KCN to form benzylcyanide 7 (Eq. 15.2.4) and followed by hydrolytic cleavage. 

Uses Powerful lacrimator was used in artillery shells and other weapons throughout World War I. Was beginning to be replaced by the more effective brom-benzylcyanide toward the close of the war. It was also used for testing of gas masks in gas chambers. 

Stephensen et al. [385] performed the displacement of a fluoro functionahty by an acyl group. In case of the benzylcyanide (514), displacement was followed by cyano displacement and air oxidation of the initially formed diaryhnethylcyanide to the corresponding benzophenone (516). After the subsequent reductive cycHzation, the desired products were obtained in yields that were variable, probably because of premature hydrolytic cleavage of the support-bound product caused by traces of OH. NMP as solvent was essential during the tin-(ll)-chloride-mediated reduction step, as it does not cause Sn(II)-promoted N-acylations Hke DMF or DMA. Attempted reductive cychzations with titanium(III) chloride or a Cu(II)-NaBH4 system failed (Scheme 102) [385]. 

The reaction of 2-cyanoquinoxaline with the anion derived from acetophenone gives some 2-(2-quinoxalinyl)acetophenone (39) and some of the imine (40). The anion derived from benzylcyanide displaces cyanide ion from 2-cyanoquinoxaline to give the disubstituted acetonitrile 41.2"... 

To eliminate the column noise caused by volatilization of the stationary phase it is advisable to insert an extra column (length 3.6m, filled with 8% DC-550 silicone oil on a solid support) between the column of silver nitrate solution in benzylcyanide and the detector [42]. 

Benzylcyanide C6H5-CH2CN 92.4+2 386.6+8.4 Derived from AfH° in ref. 2000VER... 

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