Benzyl trimer

Also, the peak for a benzyl trimer-d8 was almost as intense as that for bibenzyl-d4 the -d8 trimer must have the structure... 

A Au mdssbauer study of reaction products of trimeric l-benzyl-2-gold(I)-imidazole leading to Au carbene or Au imidazoline complexes and trinuclear Au " imidazolyl derivatives. X-Ray crystal structure of [ (p-l-benzylimidazolato-N, C )Au 3l2j. Journal of Organometallic Chemistry, 470, 275-283. 

In a few cases, the synthesis was directed towards well-defined oligomers (dimers, trimers, etc.). The synthesis of bis(5,7,3, 4 -tetra-0-benzyl)-EC 4/1,8-dimer from 5,7,3, 4 -tetra-0-benzyl-EC and 5,7,3, 4 -tetra-0-benzyl-4-(2-hydroxyethoxy)-EC was described by Kozikowski et al. [41]. This compound exhibited the ability to inhibit the growth of several breast cancer cell fines through the induction of cell cycle arrest in the Gq/Gi phase. Analogously, procyanidin-B3, a condensed catechin dimer, has been obtained through condensation of benzylated catechin with various 4-0-alkylated flavan-3,4-diol derivatives in the presence of a Lewis acid. This reaction led to protected procyanidin-B3 and its diastereomer. In particular, octa-O-benzylated procyanidin-B3 has been produced with high levels of stereoselectivity and in excellent isolation yields [42]. 

The reaction of A-benzyl-C-imidazolyllithium with [Ag(N03)(SMe)2] affords the corresponding C-imidazolylsilver (Equation (3)), which has been proposed by molecular weight determination to be trimeric.297 A-Functionalized C-imidazolylsilver compounds or carbene-type silver complexes are obtained by reaction of the imidazolium salt with Ag20 or Ag2C03 some of these are shown in Figure 4 298,299... 

Figure 10 Molecular structure of a zinc trimer (59) with bridging benzyl thiolates and a bis(benzimidazole)...

Treatment of ethenes 158 with trithiazyl trichloride afforded 1,2,5-thiadiazoles 159 in moderate to good yields (Equation 32 Table 10). The reaction, however, suffers from the possibility of chlorination at allylic or benzylic positions, in particular if excess trimer is used. 

Olefins possessing allylic hydrogens undergo reactions similar to those of aromatics with benzylic hydrogen. These reactions lead to combination of the olefins, usually to dimers and trimers. 

In this approach the C(2)-N(3) and C(6)-N(l) components are usually the same. Formamide or nitriles are common C-N components. A classical example is the trimerization of acetonitrile to give 2,6-dimethyW-pyrimidinamine <1994HC(52)1 >, while a modern example involves a similar trimerization of a variety of alkyl and benzylic nitriles 707 under microwave conditions <2005JC0483>. 

Halosilyl)styrenes undergo dimerization and trimerization on treatment with TfOH via electrophilic addition of the corresponding benzyl cation generated by protonation of the parent molecule386. 

Fig. 2. Synthesis ofcyclotriveratrylene by trimerization of 3,4-disubstituted benzyl cations...

For the construction of the cryptophanes depicted in Fig. 3, two different synthetic routes have been employed (Fig. 4). With reference to method (a), a suitably substituted benzyl alcohol is first converted to a C3-cyclotriveratrylene, to which three chains ending with benzyl alcoholic groups are attached and eventually cyclized intramolecularly in this reaction, the first cap serves as a template to direct the trimerization [14]. In a second, shorter route (b), a benzyl alcohol is first transformed into a dimer , which under suitable conditions trimerizes to a cryptophane in this reaction, six carbon-carbon bonds have to be created in a single sequence [24]. 

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