Benzyl 2-naphthyl

Allyl-(2-methyl-phenyl)-ather AllyI-(2-chlor-phcnyl)-ather Allyl-naphthyl-( l)-ather Benzyl-naphthyl-(2)-ather... 

Amine Benzyl-naphthyl-(penui-fluoro-cthyl)- ElOa. 247 (CS-CF3 -9 C2F5)... 

R = benzyl, naphthyl methyl, anthra-cenylmethyl, 4-quinolinylmethyl X= Br, Cl... 

R - = aryl, benzyl, alkyl, alkenyl R = H, phenyl, etyryl, R = H, benzyl, naphthyl... 

Deprotection of Fmoc-amino acid Wang resins under standard conditions yielded the polymer-bound amino acids 1. Condensation with 3,4-dichlorobenzaldehyde gave aldimines 2. Subsequent alkylation with electrophiles such as benzyl-, naphthyl- or allylbromide in the presence of 2-[(l,l-dimethylethyl)imino]- W,N-diethyl - 2,2,3,4,5,6- hexahydro-1,3-dimethyl-1,2,3-diazaphosphorin-2(lH)-amine (BEMP) gave the disubstituted aldimines 3. Transketalisation with hydroxylamine hydrochloride yielded the free amine 4 which was acylated and cleaved to give the final product 5 in good yields and purities. 

R = Me, Et, Ph, Furluryl, a-Pyridylmethyl, Benzyl, Naphthyl, Biphenyl, p-MeOPh, p-MePh, o-MeOPh, o-EtOPh... 

Nitio-benzyl].. naphthyl-amin 12, 1278. [3-Nitto-ben l].. naphthyl-amin 12,1278. [4-Nitro-ben l]. -naphthy. ainin 12,1278. 3-Oxy-naphthon nre 2)-[3.amino.amlid1 13 n 28. 

Bcnzyl-ot-naphthyMceton 7,. 512, II461. PhenyI.[a-naphtnyl-methyl]-keton 7 II 461. Benzyl- -naphthyl keton 7 II461. 2-Mefchyl-l- nzoyl-naphthalin 7 11 462. 

X Phenyl-dlphenoohlnondiimid 12 II124. [a-Cyan benzyl] >naphthyl-amiii 14, 468. [a-Cyaai beazyl]< naphthyl-amm 14, 468. Acenaphthenon-phenyihyaraaon IS, 148,... 

In these reactions, the resulting lactols were immediately oxidized to lactones for the ease of isolation and characterization. A variety of R-groups, including alkyl, alkyl chloride, benzyl, naphthyl, and nitrile groups, was used, with all reactions proceeding in good yield (66-92%). These reactions required slightly harsher conditions than have... 

Direct heterolytic fission of the substrate-photoprotecting group bond is the required course for photorelease of most biologically important substrates. This process avoids the generation of destructive radicals that could result in reactions such as decarboxylation, radical dimerization, or redox processes. Thus, the effect of m-substitution on the photochemistry of benzyl, naphthyl, and other aromatic chromophores has become the object of many studies in search of alternatives to the o-nitrobenzyl class of protecting group. 

Formation of 2 naphthyl ethers. Alkyl halides and aryl-alkyl halides (e.g. benzyl chloride) are converted into 2-naphthyl ethers thus ... 

Dinitrophenyl)ethyl, 187 2-Cyano-1-phenylethyl, 188 S-Benzyl Thiocarbonate, 188 4-Ethoxy-1-naphthyl, 188 Methyl Dithiocarbonate, 189... 

With secondary and tertiary alkyl halides an Ea-elimination is often observed as a side-reaction. As the alkyl halide reactant an iodide is most often employed, since alkyl iodides are more reactive than the corresponding bromides or chlorides. With phenoxides as nucleophiles a C-alkylation can take place as a competing reaction. The ratio of 0-alkylation versus C-alkylation strongly depends on the solvent used. For example reaction of benzylbromide 4 with /3-naphth-oxide 5 in yV,A-dimethylformamide (DMF) as solvent yields almost exclusively the /3-naphthyl benzylether 6, while the reaction in water as solvent leads via intermediate 7 to formation of the C-benzylated product—l-benzyl-2-naphthol 8—as the major product ... 

Piperazine, N-alkylation with benzyl chloride, 42, 19 Piperazine, 1-benzyl-, 42,19 Piperidine, addition to ethylene, 43, 45 as catalyst for Claisen-Schmidt condensation, 41, 40 Piperidine, 1-ethyl-, 43, 45 Piperidine, 1-(2-naphthyl)-, 40,74 Pivalic acid, oxidative coupling to a,a,-a, a -tetramethyladipic add, 40, 92... 

Naphthyl-benzyl-sulfone spalten vorwiegend in Naphthalinsulfinsduren und Toluol. Lediglich Methyl-naphthyl-sulfone bilden hauptsachlich Naphthalin und Methansulfin-sdure1. 

Bis-[2-bcnzoyl-phcnyl]- 678 Bis-[4-tert.-butyl-benzyl)- 625 Bis-[cyan-mcthyl]- 703 Bis-[3,4-dichlor-benzyl]- 625 Bis-[diphenylmethyl]- 609 Bis-[4-methoxy-phcnyIJ- 625 Bis-[4-methyI-benzyl]- 625 Bis-[4-methyI-phenyI]- 625 Bis-[1 -naphthyl-(l )-iithyl]- 609 Bis-[3-oxo-butyI]- 585 Bis-[tridecafluor-hexyl]- 624 Cyanmcthyl- -chlorid 702 Dibenzyl- 622 Dicyclohexyl- 609 Didecyl- 623 f. 

Hydroxy-2-phenyl-athyl)-benzyI- 633 (2-Hydroxy-2-phenyl-athyl)-phenyI- 667 [1-Hydroxy-l -phenyl-propyl-(2)J-phenyl- 633 Methyl-(2-tert.-butyl-phenyl)- 632 Methyl-(2-methyl-phenyl)- 632 Methyl-naphthyl- 663 Naphthyl-benzyl- 633 fi-Oxo- 634... 

Oxo-4,4-dimethyl-2-benzyl-4.5-dihydro- 228 5-Oxo-4-methyl-2-benzylidcn-2.5-dihydro- 228 5-Oxo-2-phenyl-4-benzyliden-4,5-dihydro- 228 5-Oxo-2-phenyl-4,5-dihydro- 228 2-Phenyl-4-ch orcarbonyl- 188 2-Phenyl-5-naphthyl-(l)- 591 2-Phenyl-5-naphthyi-(l)-2,3-dihydro- 591... 

The spiro compound 206 was prepared in five steps from (S)-l-naphthyl-ethylamine and was composed of a mixture of imine and enamine tautomers. Reduction of the imine function by sodium borohydride occurred on the less hindered si face, leading to the diamine with the R configuration of the newly formed stereo center, then the N-benzyl substituent was removed by hydrogenolysis to give 207 with good overall yield [98] (Scheme 30). 

Nucleophilic addition to a, -unsaturated sulfones has long been known. For example, treatment of divinyl sulfone with sodium hydroxide has been known to afford bis( -hydroxyethyl) sulfone "", while the reaction of a- and -naphthyl allyl sulfones and allyl benzyl sulfone " with alkali hydroxide or alkoxide gave -hydroxy or alkoxy derivatives. In the latter reaction, the allyl group underwent prototropy to the 1-propenyl group, which in a subsequent step underwent nucleophilic attack . Amines, alcohols and sulfides are known to add readily to a, -unsaturated sulfones, and these addition reactions have been studied widely. In this section, the addition of carbon nucleophiles to a, ji-unsaturated sulfones and the reactions of the resulting a-sulfonyl carbanions will be examined. 

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