5-Benzyl-2-mercapto

Acetyl imi no-4-methyl-2-benzyl-mercapto-A -1,3,4-thiadi-azoline... 

Acetamido-5-mercapto-l, 3,4-thiadiazole is prepared as described under acetazolamide. This on treatment with/>-chlorobenzyl ehloride forms the corresponding />-chloro benzyl mercapto derivative, which when reacted with methyl bromide in the presenee of sodium methoxide yields the acetylamino thiadiazoline derivative. On oxidation with aqueous ehlorine it gives rise to the 2-sulphonyl chloride derivative which finally yields methazolamide on amidation with ammonia. 

To confirm the mode of entry of C orotate into nucleated cells, the co-culture experiment in fibroblasts was repeated in the presence of the uridine uptake inhibitor nitj — benzyl mercapto inosine (NBMI). 

CxyHifBsOaS >[ct -Pbrayl>areidol >benzyl mercaptO propUmsaure 18 II 214. 

Bibenzoylderivat des 3 Amino-5-benzyl< mercapto-1 phmyl-1.3.4-triaaol9 3611144. 

MCPc Tris(benzyl-mercapto)-mono(carboxy phenoxy)-phthalocyanine... 

Mugadza T, Nyokong T (2011) Synthesis and electrocatalytic behavior of cobalt(n)-tris (benzyl-mercapto)-monoaminophthalocyanine—single walled carbon nanotube nanorods. 

Carbon disulfide readily reacts with a-aminonitriles giving 2-mercapto-5-aminothiazoles (213), (271, 293) which can be converted to 5-aminothiazoles unsubstituted in the 2-position (Scheme 110 and Table II-34a). If this reaction is carried out in the presence of benzyl chloride in phosphorus tribromide, a 2-S-substituted thiazole derivative (214) is obtained in quantitative yield (Scheme 111), with R = hydrogen or phenyl (68, 304). 

A problem associated with the use of abrasive metal poHshes is that the fresh metal, which has been exposed by the cleaning, rapidly oxidizes or tarnishes. Thus, many modem poHshes contain inhibitors. Sulfur compounds, eg, alkyl benzyl thiols, commonly are used, as are mercapto esters such as lauryl thioglycolate [3746-39-2] and dialkyldisulfides (52—54). 

Infrared and NMR spectra show that for the A-benzyl derivative the mercapto tautomer 173a (R = CHaPh) is preferred in chloroform solution, while in the solid this compound exists as the thione 173b [76AHC(S1), p. 395]. 

Triazole ring cleavage of the 7-amino-5-benzyl-5-mercapto-l,2,4-triazolo-[l,5-c]pyrimidinium iodide 135 at the N3-N4 bond occurred upon treatment with potassium carbonate to give the 4-amino-2-benzylmercapto-l-methyl-... 

Alkyl-(2-mercapto-athyl)-benzyl- 247 Alkyl-phenyl- 259 Allyl- 118, 579 Allyl-benzyl- 350 Allyl-butyl-(3-oxo-butyl)- 659 Aryl- 498, 536, 568... 

When the 3-thiourea derivative (59) was heated in boiling ethanol for 3 h, and then the evaporated reaction mixture was treated with 10% NaOH solution at 100°C for 20 min, anhydro 2-methyl-3-mercapto-4-hydroxy-5,6,7,8-tetrahydro[l,2-6]pyridazinium hydroxide (61) was obtained (71CPB159). The mercapto group was alkylated with benzyl bromide and was treated with HgCla in boiling ethanol to yield the 3-chloromercurithio derivative. Anhydro 3,4-dihydroxy-2-methyl-5,6,7,8-tetrahydropyrido[l,2-f ]pyridazinium hydroxide (62) was O-acylated with acetic anhydride, but the structure of the product was not elucidated (71CPB159). 

Methazolamide Methazolamide, N-(4-methyl-2-sulfamoyl-l,3,4-thiadiazol-5-yliden) acetamide (21.2.3), is made by an intermediate product of acetazolamide synthesis— 2-acetylamino-5-mercapto-l,3,4-thadiazol (9.7.3). This is benzylated with benzylchloride at the mercapto group, forming 2-acetylamino-5-benzylthio-l,3,4-thiadiazole (21.2.1). Further methylation of the product with methyl iodide leads to the formation of N-(4-methyl-2-benzylthio-l,3,4-thiadiazol-5-yliden)acetamide (21.2.2). Oxidation and simultaneous chlorination of the resulting product with chlorine in an aqueous solution of acetic acid, and reacting the resulting chlorosulfonic derivative with ammonia gives (21.2.3) [5-7]. 

In contrast with the meso-ionic l,2,3-triazol-4-ones (176) which are relatively stable to heat, the meso-ionic l,2,3-triazole-4- ones (196) rearrange when heated in benzene solution at 18Q°. Under these conditions, anhydro-1 -benzyl-3-methyl-4-mercapto-1,2, -triazolium hydroxide... 

The diastereoselective cycloaddition of 2-phenyl-4-dimethylamino-l-thia-3-azabuta-l,3-diene with a choice of dienophiles and in the presence of a Lewis acid provides a convenient route to 5,6-dihydro-4//-l,3-thiazines <2002TL6067, 2004T1827>. The more stable /ra r-adducts are produced exclusively. The approach using (4A)-3-acryloyl-4-benzyloxazolidin-2-one 198 provides access to the chiral 5,6-dihydro-4//-l,3-thiazine 199 <2004T1827>. The exceptional level of selectivity is only achieved when magnesium bromide is used. The chiral auxiliary was removed by reaction with lithium benzoxide to give the benzyl ester 200, and reaction with catalytic amount of samarium triflate and methanol provides the methyl ester 201 (Scheme 21). 2-Substituted-5,6-dihydro-l,3-thiazines are conveniently synthesized from nitriles or thiocyanates and 4-mercapto-2-methylbutan-2-ol to produce... 

Brom-5-formyl-l-( 4-methoxy-henzyl)-imidazol l-Benzyl-4-brom-5-carboxy-...946 /-Benzyl-4-brom-5-mercapto-...946 4-Brom-5-methoxycarbonyl-]-methyl-...1047 1033 50% 67% 68% 50% ... 

So wird aus l-Benzyl-4-brom-5-formyl-2-phenyl-imidazol und Natriumazid in 52% Ausbeute 4-Azido-l-benzyl-5-formyl-2-phenyl-imidazol erhalten, wahrend die Umsetzung von 1-Benzyl-4-brom-5-formyl-imidazol kein definiertes Produkt liefert922 Mit Mercapto-essigsaure-cthyl-ester und Natriummethanolat reagieren 1-substituierte 4-Brom-5-formyl-imidazole unter nukleophiler Substitution des Brom-Atoms durch den Thiolat-Rest und anschlieBender Kon-densation der Methylen-Gruppe mit der Aldehyd-Funktion zu den entsprechenden 2-Ethoxy-car bon yl-4H-[Pg.165]

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