Benzophenones biological activities

A third modality is based on the use of orthogonal protection during SPPS synthesis to achieve selective removal of a specific side-chain protecting group, followed by selective modification with an activated benzophenone moiety. At the conclusion of the side-chain modification, which is carried out on the resin-bound peptide, stepwise elongation of the peptide chain is resumed.11571 Table 5 provides a current summary of reported biologically active peptides substituted with a benzophenone moiety and includes some synthetic details about their preparation. 

Chattopadhyay, S.K. and Kumar, S. (2006) Identification and quantification of two biologically active polyiso-prenylated benzophenones, xanthochymol and isoxanthochymol, in Garcinia species using liquid chromatography-tandem mass spectrometry. Journal of Chromatography B 844(1), 67-83. 

CHEMISTRY AND BIOLOGICAL ACTIVITY OF POLYISOPRENYLATED BENZOPHENONE DERIVATIVES... 

Clusiaceae (Guttiferae) is a family almost exclusively tropical in distribution and comprises about 40 genera and 1200 species most of which are woody [1], Extensive phytochemical studies have shown Clusiaceae to be a rich source of secondary metabolites including xanthones, triterpenoids, flavonoids, lactones and organic acids. In addition plants of this family produce a series of oxidized and polyisoprenylated benzophenones (PBDs), some of which are structurally complex and biologically active. 

THE BENZOPHENONES ISOLATION, STRUCTURAL ELUCIDATION AND BIOLOGICAL ACTIVITIES... 

Historically, reviews of benzophenones were included as small sections with the biogenetically related xanthones. Previous reviews include Bennett and Lee [1] who discussed the distribution and isolation of 20 benzophenones included in a review focused on xanthones. They also discussed the biosynthetic relationships between xanthones and benzophenones. Kumar and Baslas [2] summarized the chemical composition, medical importance, and biologically active benzophenones, biflavonoids, and xanthones isolated from Garcinia species. Two reviews by Waterman focused on the chemotaxonomic significance of benzophenones, along with biflavonoids and xanthones, of ten African Garcinia species [3,4], Locksley and Murray [5] discussed the distribution of thirteen benzophenones in higher plants and Sultanbawa [6] included five benzophenones in a review on xanthonoids from tropical plants. Sultanbawa also discussed the biosynthesis of benzophenones and xanthones. Erdelmeier et al. [7] discussed 20 polyprenylated benzophenones in a chapter on the various properties of St. John s Wort Hypericum perforatum). 

This chapter briefly discusses benzophenone biosynthesis, lists known benzophenones and their sources, and discusses their isolation, structural determination, and biological activities. 

Dihydrophenanthrenes and Phenanthrenes Biosynthesis Biological activity Benzophenones Xanthones... 

The synthetic utility of DPM-type rearrangements now extends well beyond their application in the synthesis of natural products and biologically active systems. So, for example, dibenzobarrelenes annulated with a pyrrolinium unit (e.g., 142) and including a benzophenone counterion 143 undergo a DPM rearrangement reaction in the solid state, and the product dibenzosemibullvalene 144 serves as a phase-transfer catalyst in alkylation reactions. 

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