Benzoic acid, 2,4,6-trimethyl-, methyl

Benzoic acid, 2,4,6-trimethyl-, 56, 31 Benzoic acid, 2,4,6-trimethyl, methyl ester, 56, 63... 

Benzoic m-Toluic (Benzoic acid, 3-methyl-] p-Toluic [Benzoic acid, 4-methyl-J 3,5-Dimcthylbcnzoic [Benzoic acid, 3,5-dimcthyl-] p-Chlorobenzoic [Benzoic acid, 4-chloro-] p-Bromobenzoic [Benzoic acid, 4-bromo-J Phthalic [ 1,2-Bcnzcncdicarboxylic acid] Toluene [Benzene, methyl-] (78) m-Xylene [Benzene, 1,3-dimethyl-] (82) />-Xylene [Benzene, 1,4-dimethyl-] (74) Mesitylene [Benzene, 1,3,5-trimethyl-] (82) p-Chlorotolueno [Benzene, l-ehloro-4-methyl-] (94) p-Bromotolucnc [Benzene, l-bromo-4-methyl-] (94) o-Xylene [Benzene, 1,2-dimethyl-] (64)... 

Benzoic acid, 2-benzoyI-, methyl ester [606-28-0,21204-8641,63 Benzoic acid,4-bromo- [586-76-5], 86 Benzoic acid, 4Benzoic acid, 2-[(diethylamino)carbonyl]-, methyl ester [2659344-2], 63 Benzoic acid, 2,4-dimethoxy- [91-52-1], 31 Benzoic acid, 3,4-dimethoxy- [93-07-2], 31 Benzoic acid, 3,4-dimethyl- [619-04-5], 31 Benzoic acid, 3,5-dimethyl- [499-06-9], 86 Benzoic acid, 4-hydroxy- [99-96-7], 60 Benzoic acid, 3-methyl- [99-04-7], 86 Benzoic acid, 4-methyl- [99-94-5], 86 Benzoic acid, 2,4,6-trimethyl- [480-63-7],... 

Malonic acid, methyl- 100 48 hr. Mesitoic acid (see benzoic acid, trimethyl-) 1.0 NaOH No exchange Samuel and Ginsburg (1955)... 

The chemical structures of the majority of FMs that have been studied in wastewater treatment are given in Figs. 1-3. Figure 1 shows a variety of FM structures that include alcohols, aldehydes, and ketones, including benzyl acetate (phenylmethyl ester acetic acid), methyl salicylate (2-hydroxy-methyl ester benzoic acid), methyl dihydrojasmonate (3-oxo-2-pentyl-methyl ester cyclopentaneacetic acid), terpineol (4-trimethyl-3-cyclohexene-1-methanol), benzyl salicylate (2-hydroxy-phenylmethyl ester benzoic acid), isobornyl acetate... 

EtOH produced cleanly the cz5-la,2a-diol 5 in 81% yield. The benzoylation of the I -a-hydroxyl group in 5, which is surrounded by the two 1,3-diaxially juxtaposed methyl groups, proved to be quite difficult under the standard benzoylation conditions. However, treatment of 5 with trimethyl orthobenzoate at 100°C in the presence of a catalytic amount of benzoic acid followed by acid-catalysed hydrolysis of the resulting 1,2-cyclic orthobenzoate provided the 1-monobenzoate derivative of 5., ) Benzoylation of this monobenzoate under standard conditions afforded the desired 1,2-dibenzoate 6 ) in 95% yield. 

Dansette and Jerina25 found that cis- 1,2-glycols (34) on treatment with trimethyl orthoacetate in refluxing benzene containing a trace of benzoic acid are converted to an enantiomeric mixture of 2-methyl-2-methoxydioxolanes (orthoesters) (35 and 36). On reaction of this mixture with trimethylsilyl chloride, substitution with inversion takes place, and trans-chlorohydrin acetate (37) is formed. The chlorohydrin acetate is cyclized to an arene oxide on treatment with sodium methoxide. 

The effect of various surfactants, the cationics-eetyl trimethyl ammonium bromide (CTAB), and cetyl pyridinium chloride (CPC), the anionic-sodium lauryl sulfate (SLS), and the nonionic-polysorbate 80 (Tween 80), on the solubility and ionization constants of some sparingly soluble weak acids of pharmaceutical interest was studied (Gerakis et al., 1993). Benzoic acid (and its 3-methyl-, 3-nitro-, and 4-tert-butyl-derivatives), acetylsalicylic acid, naproxen, and iopanoic acid were chosen as model drugs. The cationics, CTAB and CPC, were found to considerably increase th< ionization constant of the weak acidS Ka ranged from-0.21 to-3.57), while the anionic, SLS, showed a negligible effect and the nonionic, Tween 80, generally decreased the ionization constants Solubility of the acids increased in aqueous micellar and in acidiLed micellar solutions. 

Dihalocycloproparenes, in particular the chloro derivatives, are extremely susceptible to hydrolysis and react via ring opening to give carboxylic acid derivatives. Typically, 1,1-dichloro-2,5-diphenylbenzocyclopropene was converted to trimethyl 2,5-diphenylorthobenzoate (12a, 94%) upon reaction with sodium methoxide in benzene and workup in the presence of base. Methanolysis in the absence of base afforded methyl 2,5-diphenylbenzoate. " The same behavior applies to 1,1-dichloro- or l,l-dibromo-2,7-diphenylcyclopropa[()]naphthalene. 1,1-Difluorobenzocyclopropene was hydrolyzed with water to benzoic acid, and the intermediate benzoyl fluoride was isolated and characterized. The hydrolysis of l,l-dihalocyclopropa[6]-naphthalenes afforded naphthalene-2-carboxylic acid, while acid-catalyzed methanolysis of... 

Aromatic acid has serious steric hindrance. If there are both ortho-methyls, just as 2.46-trimethyl benzoic acid, the alcohol molecule is so difficult to access to carboxyl that the esterification cannot occur. However, if 2.4.6- trimethyl benzoic add is dissolved in the 100% sulfuric-acid solution, acylilum ion will be formed as shown in Figure 5. Then the added alcohol with the acylilum ion produced ester. The reaction will conduct smoothly (Streitwieser et al., 1985). 

Gl Aryltriene analog of retinoic acid transY [75664-66-3] (E, )-4-[2-Methyl-4-(2,6,6-trimethyl-1 -cyclohexen-1 -yl)-1,3-butadienyl]benzoic acid... 

Treatment of methyl p-methylbenzoate with 1.2 equiv of trimethylsilyldiethylarnine and 1.3 equiv of methyl iodide in toluene, followed by gradual heating to 90 °C over a period of 4h and additional stirring at 100-110 °C provides the corresponding trimethyl silyl ester. Subsequent hydrolysis affords p-methylbenzoic acid in 85% yield based on 90% conversion (reaction monitored by GC) (eq 8). Benzoic esters substituted with an electron-donating substituent such as methyl or methoxy groups are more readily dealkylated in contrast with electron-deficient esters, such as with chlorine atom substituent, or aliphatic carboxylic acid esters. 

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