Benzoic acid, 2,4,6-trimethyl-, methyl ester

Benzoic acid, 2,4,6-trimethyl-, 56, 31 Benzoic acid, 2,4,6-trimethyl, methyl ester, 56, 63... 

Benzoic acid, 2-benzoyI-, methyl ester [606-28-0,21204-8641,63 Benzoic acid,4-bromo- [586-76-5], 86 Benzoic acid, 4Benzoic acid, 2-[(diethylamino)carbonyl]-, methyl ester [2659344-2], 63 Benzoic acid, 2,4-dimethoxy- [91-52-1], 31 Benzoic acid, 3,4-dimethoxy- [93-07-2], 31 Benzoic acid, 3,4-dimethyl- [619-04-5], 31 Benzoic acid, 3,5-dimethyl- [499-06-9], 86 Benzoic acid, 4-hydroxy- [99-96-7], 60 Benzoic acid, 3-methyl- [99-04-7], 86 Benzoic acid, 4-methyl- [99-94-5], 86 Benzoic acid, 2,4,6-trimethyl- [480-63-7],... 

The chemical structures of the majority of FMs that have been studied in wastewater treatment are given in Figs. 1-3. Figure 1 shows a variety of FM structures that include alcohols, aldehydes, and ketones, including benzyl acetate (phenylmethyl ester acetic acid), methyl salicylate (2-hydroxy-methyl ester benzoic acid), methyl dihydrojasmonate (3-oxo-2-pentyl-methyl ester cyclopentaneacetic acid), terpineol (4-trimethyl-3-cyclohexene-1-methanol), benzyl salicylate (2-hydroxy-phenylmethyl ester benzoic acid), isobornyl acetate... 

Aromatic acid has serious steric hindrance. If there are both ortho-methyls, just as 2.46-trimethyl benzoic acid, the alcohol molecule is so difficult to access to carboxyl that the esterification cannot occur. However, if 2.4.6- trimethyl benzoic add is dissolved in the 100% sulfuric-acid solution, acylilum ion will be formed as shown in Figure 5. Then the added alcohol with the acylilum ion produced ester. The reaction will conduct smoothly (Streitwieser et al., 1985). 

Treatment of methyl p-methylbenzoate with 1.2 equiv of trimethylsilyldiethylarnine and 1.3 equiv of methyl iodide in toluene, followed by gradual heating to 90 °C over a period of 4h and additional stirring at 100-110 °C provides the corresponding trimethyl silyl ester. Subsequent hydrolysis affords p-methylbenzoic acid in 85% yield based on 90% conversion (reaction monitored by GC) (eq 8). Benzoic esters substituted with an electron-donating substituent such as methyl or methoxy groups are more readily dealkylated in contrast with electron-deficient esters, such as with chlorine atom substituent, or aliphatic carboxylic acid esters. 

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