Bentyl - Dicyclomine hydrochloride

Eight reports received from pharmacists expressed concern about the labeling on the Bentyl (dicyclomine hydrochloride, an antispasmodic) 2 ml ampul. Practitioners reported that the label indicates only the drug concentration, lOmg/ml, and not the total volume. Some practitioners believe the label information is incomplete. In one report, a 20 mg dose was ordered, but two ampuls were administered (4 ml total instead of 2 ml), leading to an overdose. This happened because the reporter mistook 10 mg as the total contents of one vial. 

Dicyclomine hydrochloride (Bentyl, others), flavoxate hydrochloride (Urispas, others), oxybutynin chloride (Ditropan, others), and tolterodine tartrate (Detrol) are tertiary amines and trospium chloride (Sanctura) is a quaternary amine all are used for their anfispasmodic properties. These agents appear to exert some nonspecific direct relaxant effect on smooth muscle. In therapeutic doses, they decrease spasm of the G1 tract, biliary tract, ureter, and uterus. 

DIcydomine Hydrochloride, USP. Dicyclomine hy. drochloride, 2-(diethylamino)ethyl bicyclohcxyl-l-carbox-ylate hydrochloride (Bentyl). has. some muscarinic receptor subtype. selectivity. It binds more firmly to Mi and Mttlian to M and Mj receptors. ... 

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