Benign proliferative epithelial

Breasts Susceptibility factors for benign proliferative epithelial disorders of the breast have been the subject of a cohort study of 68 132 postmenopausal women who were prospectively followed those who had an open surgical biopsy or a core needle biopsy had histological sections obtained for centralized pathology review. Over an average of 7.8 years of follow-up, 1792 women with benign proliferative disorders were identified. Women who had used postmenopausal hormones for 15 years or more had a twofold increase in the risk of such disorders of the breast compared with women who had never used postmenopausal hormones (HR = 2.03 95% Cl = 1.73, 2.38) and the increase in risk was observed both for proliferation without atypia and for atypical hyperplasia. Furthermore, the risk of such complications decreased with time since cessation of use so that there was essentially no increase in risk five or more years after withdrawal of HRT [25. ... 

Cui Y, Page DL, Lane DS, Rohan TE. Menstrual and reproductive history, postmenopausal hormone use, and risk of benign proliferative epithelial disorders of the breast a cohort study. Breast Cancer Res Treat 2009 114(1) 113-20. 

Furthermore, much interest has evolved regarding the role of K5/K14 in breast pathology in several aspects, especially in the classification of benign proliferative lesions and ductal and obular in situ neoplasia (Otterbach et al. 2000). A typical example of a benign epithelial proliferation is shown in Fig. 13.7. 

Anreder, M. B., Freeman, S. M., Merogi, A., Halabi, S., and Marrogi, A. J. 1999. p53, c-erbB2, and PCNA status in benign, proliferative, and malignant ovarian surface epithelial neoplasms. Arch. Pathol. Lab. Med 723 310-316. 

FIGURE 19.37 Proliferative activity in fibroadenomas versus benign phyllodes tumors. The fibroadenoma depicted in (A) and (B) shows no Ki-67 positive stromal cells, whereas that depicted in (C) and (D) shows focal ( 1 %) Ki-67 stromal cell immunoreactivity. Note the numerous positive ductal epithelial cells. Similarly, a benign phyllodes tumor may show minimal or no proliferative activity with Ki-67 as shown in (E-H). 

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