Beneficial Actions of CR Based On the Adaptive Response Hypothesis

Interpretation of the Beneficial Actions of CR Based On the Adaptive Response Hypothesis 

Adaptive responses against food shortage through altered neuroendocrine system 

low adiposity with small adipocytes (lower leptin higher adiponectin) 

slow skeletal maturation and slow sexual maturation 

altered energy and lipid metabolism (metabolized carbohydrate as fuel activated fatty acid synthesis after feeding in the liver) (metabolized fat as fuel activated (3-oxidation prior to feeding in the liver) 

---