Beadle

Submitted by Stephen A. DiBlase, James R. Beadle, and George W. Gokel. ... 

Closely related to the crown ether adducts are the two intramolecular arenediazonium ion-crown ether compounds 11.6 and 11.7 which were synthesized by Gokel s group (Beadle et al., 1984b). Infrared and lH NMR spectra are consistent with the insertion of the diazonio group into the 21-crown-7 cavity. The complex 11.6 can therefore be described not in an anthropomorphic, but in a zoomorphic way, as an ostrich complex reflecting the common belief that an ostrich hides its head in a hole when endangered. For the complex 11.7 the spectra correspond to... 

Complexation with crown ethers increases the notoriously low solubilities of diazonium salts in most solvents (with the obvious exception of water). Therefore, it is possible to carry out phase-transfer reactions with complexed diazonium ions (review Gokel et al., 1985). Useful examples can be found in a paper from Gokel s group (Beadle et al., 1984a) on the Gomberg-Bachmann and Pschorr reactions (see Sec. 10.10). 

Balzarini J, Schols D, Van Laethem K, De Clercq E, Hockovd D, Masojidkova M, Holy A (2007) Pronounced in vitro and in vivo antiretroviral activity of 5-substituted 2,4-diamino-6-[2-(phosphonomethoxy)ethoxy]pyrimidines, J Antimicrob Chemother 59 80-86 Beadle JR, Wan WB, Ciesla SL, Keith KA, Hartline C, Kern ER, Hostetler KY (2006) Synthesis and antiviral evaluation of alkoxyalkyl derivatives of 9-(S)-(3-hydroxy-2-phosphonomethoxypropyl)adenine against cytomegalovirus and orthopoxviruses, J Med Chem 49 2010-2015... 

Dal Pozzo F, Andrei G, Lebeau I, Beadle JR, Hostetler KY, De Clercq E, Snoeck R (2007) In vitro evaluation of the anti-orf virus activity of alkoxyalkyl esters of CDV, cCDV and (S)-HPMPA. Antiviral Res 75 52-57... 

Quenelle DC, Collins DJ, Wan WB, Beadle JR, Hostetler KY, Kern ER (2004) Oral treatment of cowpox and vaccinia virus infections in mice with ether Upid esters of ddofovir. Antimicrob Agents Chemother 48 404-412... 

Wyles DL, Schooley RT, Kaihara KA, Beadle JR, Hostetler KY (2008) Anti-hepatitis C virus repli-con activity of alkoxyalkyl esters of (S)-HPMPA and other acyclic nucleoside phosphonates. In Abstracts of the 21st international conference on antiviral research, Montreal, QC, Canada, 13-17 April 2008. Antiviral Res 78 A21, no 15... 

Neurospora crassa is a filamentous pink mould. It became famous to scientists due to the work of Beadle and Tatum in the 1940s when they developed the one gene—one enzyme hypothesis. Its life cycle is shown in Fig. 2.9. Unforturrately, the full force of fungal nomenclature comes into play when considering this organism. Aerial hyphae... 

The hydroxylase that converts 2,4-dichlorophenol into 3,5-dichlorocatechol (Figure 3.14a) before ring fission has been purified from a strain of Acinetobacter sp. (Beadle and Smith 1982), and ixomAlcaligenes eutrophus IMP 134 (Don et al. 1985 Perkins et al. 1990). The reductant is NADPH, the enzyme is a flavoprotein containing FAD, and in the presence of compounds that are not substrates, NADPH and O2 are consumed with the production OfH202. 

Beadle TA, ARW Smith (1982) The purification and properties of 2,4-dichlorophenol hydroxylase from a strain of Acinetobacter species. Eur J Biochem 123 323-332. 

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