Batch Fluid Bed Granulation

Synthon Pharmaceuticals Inc., Research Triangle Park, North Carolina, U.S.A. Martin Mogavero 

Wolf (7) discussed the essential construction features of the various fluid bed components, and Liske and Mobus (8) compared the fluidized bed and traditional 

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Figure 20-87 shows a typical production-size batch fluid-bed granulator. The air-handling unit dehumidifies and heats the inlet air. Heated fluidization air enters the processing zone through a distribu-... 

Parikh DM, Bonck JA, Mogavero M. Batch fluid bed granulation. In Handbook of Pharmaceutical Granulation Technology. New York Marcel Dekker, 1997, pp 227-331. 

Figure 151 depicts the principal features of a batch fluid bed granulator. It consists of a conical fluidization chamber and cylindrical housing, in which a filter may be directly installed. At the bottom, a cloth with openings between approximately 50 and 100 m is supported by a perforated plate and serves to uniformly distribute the fluidization gas entering from the plenum below. The gas, which may be heated, is sucked through the apparatus by the exhaust fan. Gas velocities at the bottom of the fluidization chamber are between 0.4 and 1.5 m/s (referred to the open cross section) and inlet temperatures may be between 40 and 200°C. The exhaust temperature is limited by the thermal stability of the filter cloth. 

Figure 152. Diagram depicting a batch fluid bed granulator with external dust collection ...

Fig. 6.2-18 left) The principle of batch fluid-bed granulation right) the outline of an apparatus (courtesy Glatt, Binzen, Germany) Fig. 6.2-19 P ID ofa typical batch fluid-bed granulation system (courtesy Glatt, Binzen, Germany)...

Fig. 6.2-20 Two batch fluid-bed granulation units (courtesy Glatt, Binzen, Germany)...

Fig. 6.2-22 Batch fluid-bed granulation unit with two mid-sections...

In a relatively new development, the distribution plate in a batch fluid-bed granulator is replaced by a solid rotating plate fitted into a conical bottom section [B.97]. Process air enters the apparatus through the annular space between the plate and the container walls. Its amount can be varied by changing the annular gap width... 

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