Basal laminas keratin

Plakin proteins link intracellular keratin intermediate filaments to hemidesmosomes of basal epidermal cells, or to desmosomes on suprabasal epidermal cells (Sect. 5.2.1), whereas type XVII collagen (the only collagen secreted by epithelial cells ) and integrins attach hemidesmosomes to a basal lamina. Three p 1 integrins (with al, a3 or a5 partners)... 

One form of cellular demise common to epithelial cells is detachment-initiated apoptosis, also referred to as anoikis (Frisch and Francis, 1994). Epidermal keratinocytes rely on signals derived from the surrounding extracellular matrix for survival. It is possible that loss of these signals plays a role in SM-induced epidermal cell injury, and that cell detachment from the basal lamina precedes cytotoxicity. Several lines of evidence support this possibility. First, SM can alter the dynamics of cytosolic proteins that exert control over the attachment of cells to the basement membrane. For example, SM can modify intracellular actin microfilaments and keratin intermediate filaments known to be important in maintaining epithelial cell connections with the basal lamina. Thus, Hinshaw et al. (1999) reported that SM causes changes in the actin microfilament architecture and morphology of human keratinocytes within 3h of... 

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