Basal ganglia structure

Brain morphometric studies of cocaine abusers have revealed evidence for enlargement of caudate and puta-men during initial abstinence, but no evidence for changes in total brain volume or volume of medial temporal lobe structures (Jacobsen et ah, 2001 a,b). Enlargement of basal ganglia structures likely reflects dopamine depletion that appears to develop following cessation of chronic cocaine use. 

Bogerts B, Falkai P, Haupts M, Greve B, Ernst S, et al. 1990. Post-mortem volume measurements of limbic system and basal ganglia structures in chronic schizophrenics Initial results from a new brain collection. Schizophr Res 3 295-301. 

The D2 receptor distribution in the basal ganglia structures has been extensively studied in relation to the role of these receptors in the control of movements and their involvement in Parkinson s disease, as it has happened for all the other features of the organization and regulation of the dopaminergic innervation of the striatum. 

Ingham CA, Stephens B, Arbuthnott GW (2002) Structural plasticity in Parkinson s disease. In Faull RLM, Nicholson LFB (Eds), The Basal Ganglia Structure and Function VII, pp. 333-340. Kluwer Academic Publishing, Boston. 

Substantia nigra (s9b- stan(t)-she-a- nT-gr3) Literally black substance, this basal ganglia structure is darkly pigmented produces dopamine. Dantage to this area produces Parkinson s disease (Chapter 3). 

Breysse N, Amalric M, Salin P (2003) Metabotropic glutamate 5 receptor blockade alleviates akinesia by normalizing activity of selective basal-ganglia structures in parkinsonian rats. J Neurosci 23 8302-8309... 

Rose C, Butterworth RF, Zayed J, et al. 1999. Manganese deposition in basal ganglia structures results from both portal-systemic shunting and liver dysfunction. Gastroenterology 117 640-644. 

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