Bacitracin polymyxin B, topical

Bacitracin Polymyxin B, Topical (Polysporin) Bacitracin, Neomycin, Polymyxin B, Topical (Neosporin Ointment) Bacitracin, Neomycin, Pol5rm5 xm B, Hydrocortisone, Topical (Cortisporin)... 

Systemic therapy with a variety of (3-lactams, macro-lides and lincosamides (clindamycin) has been the cornerstone of skin infection therapy for many years [17]. However, topical antibiotics can play an important role in both treatment and prevention of many primary cutaneous bacterial infections commonly seen in the dermatological practice [18], Indeed, while systemic antimicrobials are needed in the complicated infections of skin and skin structure, the milder forms can be successfully treated with topical therapy alone [18], The topical agents used most often in the treatment of superficial cutaneous bacterial infections are tetracyclines, mupirocin, bacitracin, polymyxin B, and neomycin. 

Antibiotic therapy should be limited to periods of disease exacerbation, with the eyelid hygiene providing the daily maintenance regimen. Occasionally, topical erythromycin, bacitracin, or bacitracin-polymyxin B ointment applied at bedtime for several weeks proves beneficial as part of the therapeutic protocol. This type of chronic therapy, however, always carries the risk of fitster-ing overgrowth of resistant organisms. 

Bacitracin, Neomycin, Polymyxin B, Lidocaine, Topical (Clomycin)... 

Polymyxin B is effective against many gramnegative bacteria, including E. coli, Klebsiella, and Salmonella. Systemic administration of this drug, however, is often associated with extreme nephrotoxicity. Hence, this agent is used primarily for the treatment of local, superficial infections of the skin, eyes, and mucous membranes. When applied topically for these conditions, adverse reactions are relatively rare. Polymyxin B is often combined with other antibiotics such as bacitracin and neomycin in commercial topical preparations. 

Owing to their significant toxicity with systemic administration, polymyxins are now restricted to topical use. Ointments containing polymyxin B, 0.5 mg/g, in mixtures with bacitracin or neomycin... 

Like polymyxin B, gramicidin changes permeability characteristics of the cell membrane, thus killing the cell. However, in contrast to polymyxin B, gramicidin is effective against gram-positive bacteria. It replaces bacitracin in some fixed-combination antibacterial solutions used topically for ocular infections (see Table 11-6). 

Note Bacitracin is supplied in many forms and vehicles Intramuscular topical, ophthalmic, otic, aerosols, for irrigations. Many Bacitracin ointments are combinations with Neomycin and Polymyxin B. 

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