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Aziridine-ring cleavage activation

Cleavage of aziridines has been employed in the asymmetric total synthesis of pancratistatin 57 [47], a compound that is the object of considerable attention thanks to its broad spectrum of antineoplastic activities [48]. The chemistry of vinylaziridines has for the most part been confined to their use in rearrangement sequences resulting in functionalized pyrrolines. Hence, because of the lack of data concerning the ring-opening of vinylaziridines with carbon nucleophiles,... [Pg.300]

The principal manner for organometallic reagents to react with activated aziridines and the 0-analogous oxiranes as well is ring opening through nucleophilic addition accompanied by heterolytic cleavage of the carbon-heteroatom bond (see below). Other favorite modes, in particular, a-metalation and P-elimination are evoked in later sections (pp. 3.5.1 and 3.5.2). [Pg.70]

See other pages where Aziridine-ring cleavage activation is mentioned: [Pg.59]    [Pg.64]    [Pg.401]    [Pg.133]    [Pg.71]    [Pg.423]    [Pg.172]    [Pg.423]    [Pg.5]    [Pg.97]    [Pg.1941]    [Pg.81]    [Pg.62]    [Pg.402]    [Pg.273]    [Pg.64]    [Pg.27]    [Pg.300]    [Pg.251]    [Pg.64]    [Pg.64]    [Pg.261]    [Pg.179]    [Pg.42]    [Pg.284]    [Pg.7]    [Pg.84]    [Pg.64]    [Pg.355]    [Pg.388]    [Pg.96]    [Pg.341]    [Pg.59]    [Pg.102]    [Pg.84]    [Pg.247]    [Pg.86]   
See also in sourсe #XX -- [ Pg.62 , Pg.63 ]



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Aziridine ring

Aziridine-ring cleavage

Aziridines cleavage

Ring activation

Ring cleavage

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