Autoimmunity pathogen-induced

Comment. Are there inherent errors in the installment of AID, APOBEC, RAG 1/2 and Revl in the superb adaptive immune system and DNA repair machinery, that could not be corrected as yet by the still evolving vertebrate mammalian (human) host Are reactivated ancient retroviral LTR inserts pathogenic (inducers of autoimmune and malignant diseases) Detailed assessment follows later. 

Autoimmunity. In autoimmunity, as with hypersensitivity, the immune system is stimulated by specific responses that are pathogenic, and both tend to have a genetic component that predisposes some individuals more than others. However, as is the case with hypersensitivity, the adverse immune response of drug-induced autoimmunity is not restricted to the drug itself, but also involves a response to selfantigens. 

Although H. pylori induces chronic infection whereas C. jejuni induces an acute infection (and to which the structural characteristics and biological properties of endotoxin, particularly their lipid A components contribute), both bacteria induce pathogenic autoimmune responses in which molecular mimicry in the... 

Langrish, C.L. et al. (2005) IL-23 drives a pathogenic T cell population that induces autoimmune inflammation. The Journal of Experimental Medicine, 201, 233-240. 

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