Autoantibodies neonatal lupus

Neonatal lupus is caused by cross-reaction between maternal antibodies and fetal tissue. It is particularly interesting because it provides a unique opportunity for studying the pathogenic role of autoantibodies. 

Compared with anti-dsDNA, relatively fewer studies have been performed on anti-Ro/La antibodies. However, the unique ability to demonstrate the pathogenic role of autoantibodies causing disease provides us a chance to explore the mechanism of human autoimmune disease. The possibly most important task is to identify the cofactors making the infants of mothers with anti-Ro/La vulnerable to developing neonatal lupus syndromes. 

D13. Dorner, T., Feist, E., Pruss, A., Chaoui, R., Goldner, B., and Hiepe, F., Significance of autoantibodies in neonatal lupus erythematosus. Int. Arch. Allergy Immunol. 123, 58-66 (2000). 

Silverman, E. D., Buyon, J., Laxer, R. M., Hamilton, R., Bini, R, etal., Autoantibody response to the Ro/La particle may predict outcome in neonatal lupus erythematosus. Clin. Exp. Immunol. 100, 499-505 (1995). 

F8. Franco, H. L., Weston, W. L., Peebles, C., Forotol, C., and Phanuphals, P., Autoantibodies directed against sicca syndrome antigens in the neonatal lupus syndrome. /. Am. Acad. Dermatol. 4, 67-72 (1981). 

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