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Aurachin

Transposon-based approaches have also been applied to myxobacteria (Figure 3). Mutants from transposon libraries can be analyzed chemically by comparison of their secondary metabolite profiles with the wild-type strain, or screened for altered bioactivity, for example, by overlay assays. This strategy was successfully used to identify the biosynthetic gene clusters responsible for the known metabolites tubulysin, disorazol, aurachin, and DKxanthene in the genomes of their respective producer strains, and has the potential to detect novel, as yet unidentified compounds and their corresponding biosynthetic pathways and regulatory elements (see Section 2.07.5). [Pg.193]

Figure 8 Type II PKS biosynthesis In myxobacteria. Biosynthesis of aurachin D (19) In Stigmatella aurantiaca Sg a15. The biosynthetic steps that are catalyzed by the gene products (AuaA-AuaE) from the aurachin core cluster are shown (AuaA, prenyl transferase AuaB, ACP AuaC, KSa AuaD, KS/3 and AuaE, benzoate CoA ligase). Binding of anthranlloyl-CoA to the ACP domain has not been proven experimentally, so direct binding of the starter unit to the KSa might be possible. Figure 8 Type II PKS biosynthesis In myxobacteria. Biosynthesis of aurachin D (19) In Stigmatella aurantiaca Sg a15. The biosynthetic steps that are catalyzed by the gene products (AuaA-AuaE) from the aurachin core cluster are shown (AuaA, prenyl transferase AuaB, ACP AuaC, KSa AuaD, KS/3 and AuaE, benzoate CoA ligase). Binding of anthranlloyl-CoA to the ACP domain has not been proven experimentally, so direct binding of the starter unit to the KSa might be possible.
H. (1987) The aurachins, new quinoline antibiotics from myxobacteria production, physico-chemical and biological properties. J. Antihiot., 40 (3), 258-265. [Pg.479]

Aurachin RE Antibacterial CYP1050A1 (RauA) Rhodococcus eryth-ropolis JCM 6824 Hydroxylation of aurachin RE intermediate 3WEC [338, 346]... [Pg.280]

Fig. 6.20 Aurachin RE a tuberculosis (TB) drug, and oxidative modification of menaquinone by M tuberculosis CYP128A1. a Aurachin RE an alkaloid antibiotic with anti-TB activity through its inhibition of menaquinone biosynthesis (enzyme MenA) [339], R. erythropolis RauA (CYP1050A1) catalyzes the N-hydroxylation of an aurachin intermediate to produee the aetive auraehin RE compound [337], b Dihydromenaquinone MK9, the major quinol electron carrier in Mtb respiration, is likely... Fig. 6.20 Aurachin RE a tuberculosis (TB) drug, and oxidative modification of menaquinone by M tuberculosis CYP128A1. a Aurachin RE an alkaloid antibiotic with anti-TB activity through its inhibition of menaquinone biosynthesis (enzyme MenA) [339], R. erythropolis RauA (CYP1050A1) catalyzes the N-hydroxylation of an aurachin intermediate to produee the aetive auraehin RE compound [337], b Dihydromenaquinone MK9, the major quinol electron carrier in Mtb respiration, is likely...
Nachtigall J, Schneider K, Nicholson G, Good-fellow M, Zinecker H, Imhoff JF, Sussmuth RD, Fiedler HP (2010) Two new aurachins from Rhodococcus sp Acta 2259. J Antibiot (Tokyo) 63 567-569... [Pg.389]

Pistorius D, Li Y, Sandmann A, Muller R (2011) Completing the puzzle of aurachin biosynthesis in Stigmatella aurantiaca sg-al5. Mol Biosyst 7 3308-3315... [Pg.389]

Yasutake Y, Kitagawa W, Hata M, Nishioka T, Oza-ki T, Nishiyama M, Kuzuyama T, Tamura T (2014) Structure of the quinoline N-hydroxylating cytochrome P450 RauA, an essential enzyme that confers antibiotic activity on aurachin alkaloids. FEBS Lett 588 105-110... [Pg.389]

AuaAE Genes required for quinoline alkaloid aurachin synthesis... [Pg.716]

Aurachin A (see Scheme 24.15) Stigmatella aurantiaca (gramnegative bacterium) [41]... [Pg.788]

Scheme 24.15 Biosynthesis (for Aurachin A-D) and biogenesis of the Aurachin alkaloids... Scheme 24.15 Biosynthesis (for Aurachin A-D) and biogenesis of the Aurachin alkaloids...
Hofle G, Kunze B (2008) Biosynthesis of aurachins A-L in Stigmatella aurantiaca a feeding study. J Nat Prod 71 1843-1849... [Pg.855]

Sandmarm A, Dickschat J, Jerike-Kodama H, Kunze B, Dittmann E, Muller R (2007) A type II polyketide synthase from the gram-negative bacterium Stigmatella aurantiaca is involved in aurachin alkaloid biosynthesis. Angew Chem Int Ed 46 2712-2716... [Pg.857]

See other pages where Aurachin is mentioned: [Pg.123]    [Pg.123]    [Pg.123]    [Pg.197]    [Pg.200]    [Pg.200]    [Pg.200]    [Pg.201]    [Pg.201]    [Pg.62]    [Pg.63]    [Pg.439]    [Pg.1240]    [Pg.277]    [Pg.310]    [Pg.312]    [Pg.123]    [Pg.788]    [Pg.788]    [Pg.817]    [Pg.819]    [Pg.829]    [Pg.830]    [Pg.830]    [Pg.832]    [Pg.832]   
See also in sourсe #XX -- [ Pg.85 , Pg.123 ]

See also in sourсe #XX -- [ Pg.85 , Pg.123 ]

See also in sourсe #XX -- [ Pg.85 , Pg.123 ]

See also in sourсe #XX -- [ Pg.163 , Pg.166 , Pg.193 ]



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Aurachins

Aurachins

T> Asiaticoside Aurachin

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