Benzodiazepines attentional abilities

Another test requiring focused attention is digit or letter cancellation, in which subjects mark through a certain numeral in a page of random numbers or a certain letter in a page of text or random letters. The typical duration of cancellation tests is 1 to 2 min. Two studies reported that diazepam (10 or 15 mg)157 and lorazepam (1 and 2 mg)124 impaired digit cancellation performance. Interestingly, Brown et al.157 found that impaired focused attention was not correlated with the ability to encode associative information. These studies confirm numerous previous studies that reported benzodiazepine-induced decrements in cancellation tests.7... 

Prior use of benzodiazepines or opiates limits the psychotomimetic effects of ketamine. There has been a double-blind, placebo-controlled study of the role of lorazepam in reducing these effects after subanesthetic doses of ketamine in 23 volunteers who received lorazepam 2 mg or placebo, 2 hours before either a bolus dose of ketamine 0.26 mg/kg followed by an infusion of 0.65 mg/kg/hour or a placebo infusion (438). The ability of lorazepam to block the undesirable effects of ketamine was limited to just some effects. It reduced the ketamine-associated emotional distress and perceptual alterations, but exacerbated the sedative, attention-impairing, and amnesic effects of ketamine. However, it failed to reduce many of the cognitive and behavioral effects of ketamine. There were no pharmacokinetic interactions between subanesthetic doses of ketamine and lorazepam. 

The available pharmacological studies generally support, with some conflicting results, the empirically acknowledged sedative and anxiolytic effects of Passiflora, but it is not yet clear which constituents are responsible for these actions. One possibility which has received attention is related to the ability of flavonoids to bind to benzodiazepine receptors. The acute toxicity is very low. 

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