Atropine methyl nitrate

Lethality was prevented by treatment with nasal atropine (atropine methyl nitrate) and post-exposure treatment with atropine methyl bromide instillation in combination with pulmonary therapeutic surfactants or liquevents in guinea pigs exposed to approximate LC50 concentrations of VX aerosol (Nambiar et ah, 2007) this concept shows promise for operational application in emergency response. 

Clinton, M.E., Misulis, K.E., Dettbam, W-D. (1988). Effects of phenytoin, ketamine, and atropine methyl nitrate in preventing neuromuscular toxicity of acetylcholinesterase inhibitors soman and diisopropylphosphorofluoridate. J. Toxicol. Environ. Health 24 439-49. 

SYNS ATROPINE METHONITRATE ATROPINE METHYL NITRATE EKOMINE EUMIDRINA EUMYDRIN EUROPEN HARVATRATE 3-0-HYDROXY-8-METHYL-l-a-H,5-a-H-TROPANIUM NITRATE ( )-TROPATE (ESTER) dl-HYOSCYAMINE METHAXNITRATE dl-HYOSYAMINE METHYL-NITRATE METANITE METHYL ATROPINE NITRATE N-METHYLATROPINE NITRATE N-METHYLATROPINTUM NITRATE METROPINE PYLOSTROPIN... 

Common Name Atropine methyl nitrate Common Name Eumydrin Chemical Type Glycolic acid ester Tox fhim B023... 

If rats, during a brief hexobarbitone anaesthesia, are intravenously injected with barely sublethal doses of organo-phosphorus cholinesterase inhibitors which are able to pass the blood-brain barrier, the animals produce a hypothermia of 4-6° in 2-3 h, followed by spontaneous recovery in 12-20 h. This phenomenon has also been demonstrated in mice but not in guinea pig or rabbit. A few clinical reports of human cases of organo-phosphate poisoning mention a severe drop in the body temperature of the victims. The anticholinesterase hypothermia in the rat can partly be prevented by systemic atropine, but not by atropine methyl nitrate (for details and references, see Meeter, 1971a). 

Atropine methyl nitrate, phenytoin, and ketamine have been reported to prevent neuromuscular toxicity of soman and DFP in rats (Clinton et al. 1988). 

DFP administered to rats produced muscle fiber discharges from the peripheral nerves as well as from the central nervous system (Clinton et al. 1988). This was significantly rednced when the animals were pretreated with atropine methyl nitrate, ketamine, or phenytoin. 

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