Atropine adsorption

Alkaloids (most alkaloids are pharmacologically active and many are of therapeutic value) Tropane alkaloids Scopolamine, apoatropine and atropine Adsorption Partisil Diethyl ether/ methanol (90 10) plus one per cent diethylamine... 

Zvirblis P, Kondritzer AA Adsorption of H BZ and C atropine to the mitochondrial fraction of the rat hrain. Edgewood Arsenal... 

Magnesium oxide is a basic compound and as such can react with acidic compounds in the solid state to form salts such as Mg(ibuprofen)2 or degrade alkaline-labile drugs. Adsorption of various drugs onto magnesium oxide has been reported, such as antihistamines, antibiotics (especially tetracyclines), salicylates, atropine sulfate, hyoscyamine hydrobromide, paracetamol, chloroquine, and anthranilic acid derivatives have been reported to adsorb onto the surface of magnesium... 

Singh A, Mital H. Adsorption of atropine sulfate and hyoscyamine hydrobromide by various antacids. Acta Pharm Technol 1979 25(3) 217-224. 

Of the two effects, the solubility effect is usually the stronger. Thus, in the adsorption of hyoscine and atropine on magnesium trisilicate it was noted that hyoscine, although in its completely unionised form, was less strongly adsorbed than atropine, which at the pH of the experiment was 50% ionised. The reason for this apparently anomalous result is clear when the solubilities of the two bases are considered. Hyoscine base is freely soluble (1 in 9.5 parts of water at f5°C) compared with atropine base (f in 400 at 20°C). Even when 50% ionised, atropine is less soluble than hyoscine and consequently is more strongly adsorbed. 

Carbon-13 n.m.r. and mass spectrometry have become essential methods in quantitative analysis of alkaloid mixtures extracted from plants, in addition to g.l.c. and photometry. Study of the mechanism of fragmentation of 3-substi-tuted tropanes is a useful tool for analysis of mixtures of tropane alkaloids. A comprehensive study on the n.m.r. spectroscopy of tropane alkaloids included most major representatives of this class. Other papers deal with the n.m.r. spectra of cocaine metabolites and derivatives. A radioimmunassay of atropine and benzoylecgonine in urine was published. Photometric determination of tropane derivatives in chloroform extracts was done via colorimetry of the bromocresol purple complex.Adsorption chromatography methods have been used with different resins. ... 

Leroy and Nicolas reported that atropine extracted from belladonna powder could be assayed by HPLC-ED, but the only antimuscarinic drug that appears to have been assayed in biological samples by HPLC-ED is hyoscine (scopolamine. Figure 6.14). An unmodified silica column was used with acetonitrile-aq. ammonium nitrate (0.1 molL pH 8.9) (9 -f 1) as eluent. Hyoscine, apohyoscine (a hyoscine metabolite) and iV-ethylnorhyoscine (Figure 6.14), the internal standard, were detected at PGEs (-1-0.9 V V5 Pd). The method was applied to urine, which was extracted with toluene under alkaline conditions. The analytes were concentrated by adsorption onto acid-prepared cyanopropyl-modified silica SPE columns and eluted with HPLC eluent. The LoD was lpgL (5mL sample). 

Khalil, S.A.H., and El-Masry, S., 1974, Adsorption of Atropine and Hyoscine on Magnesium Tiisihcate , Journal of Pharmaceutics and Pharmacology, 26, pp 243-248. Khahl, S.A.H., Mortada, L.M., Shams-Eldeen,M.A., and El-Khawas,M.M., 1987, The in vitro Uptake of a Low Dose Drur (Riboflavine) by Some Adsorbents , Drug Development and Industrial Pharmacy, 13(3), pp 547-563. 

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