Atracurium besilate

C3H3CIO 814-68-6) see Atracurium besilate Ac-Thr-Gly-Trp-Met-Asp-Phe-NH2.HCI (C37H49C1NhO ( S 17664-80-1) see Ceruletide adamantane... 

C5 H N20 2 64228-77-9) see Atracurium besilate iV-[2-(3,4-dimethoxyphenyl)-l-methylethyl]-4-ethoxy-3-methoxybenzeneacetamide (C22H29NO5 93-31-2) see Dimoxyline... 

C20H25NO4 73074-37-2) see Atracurium besilate (/t)-tetrabydropapaverine 7V-acetyl-L-leucinate (C2gH4(,N207 141109-12-8) see Cisatracurium besylate ( )-tetrabydropapaverine bydrocbloride (C20H26CINO4 6429-04-5) see Cisatracurium besylate [ -( , 5 )]-2,3,4,9-tetrabydro-7V-(l-phenylethyt)-lff-carbazol-3-amine sulfate (1 1)... 

In some cases hydrochloride salts are not very water soluble due to the strength of association between the base and its counter ion, and other salts have to be used. For instance, salts may be prepared with di- or tricarboxylic acids, e.g. ergometrine tartrate, diethylcarbamazine citrate, sumatriptan succinate (Fig. 3.18) and lisuride maleate are all used because of the water insolubility of their hydrochlorides. Similarly strong monobasic organic acids such as mesilate are used to promote water solubility, as in the case of benzatropine mesilate (Fig. 3.18) andphentol-amine mesilate. In some instmces salts are too ready to absorb water from the atmosphere, for instance the muscle relaxant dmg atracurium is formulated as its besilate salt to avoid the problems of water absorption experienced with its mesilate. 

R-cis R-cis isomer of atracurium. It is degraded by Hofmann elimination just like atracurium. However, plasma concentrations of laudanosine do not reach such high levels as in the case of atracurium, leading to fewer cardiac side effects. Cisatracurium also releases less histamine from tissue stores. The potency and duration of action are similar in both drugs. Cisatracurium besilate is provided in sterile injections with a concentration equivalent to 2 mg/mL of cisatracurium in 5- or 10-mL vials, or 10 mg/mL of cisatracurium in 20-mL vials intended for use in ICUs only. 

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