ATPases associated with a variety of cellular

AAA ATPases associated with a variety of cellular activities E(MFP)AB 87(122) 112(159) 1BMF... 

The six ATPases belong to the rather large family of AAA ATPases (for ATPases Associated with a variety of cellular Activities) whose eukaryotic members include the motor protein dynein, the membrane fusion factor NSF, and the chaperone... 

Sequence motifs [33330 ANK (ANKyrin-like) repeats AAA (ATPases associated with a variety of cellular activities) domain or CAD (conserved ATPase domain) with Walker A and B motifs KEKE (motif rich in alternating lysine (K) and glutamate (E) residues) cys box of UBPs (ubiquitin-processing enzymes) nun- LRR (leucine-rich repeat)-like motif [ZD MPN (found in Mprland Padl in the N terminus) motif ISSSSSSS PCI (for proteasome, COP9andinitiation factor 3) motif H UCH (ubiquitin C-terminal hydrolases) block. 

One striking difference that dynein exhibits compared to kinesins and myosins is that dynein has AAA (ATPases Associated with a variety of cellular Activities) modules [ 77-79], which indicate that its mode of working will be entirely different from kinesins and myosins. This puts dyneins into the AAA superfamily of mechanoenzymes. The dynein heavy chains contain six tandemly linked AAA modules [80,81] with the head having a ring-like domain organization, typical of AAA superfamily. Four of these are nucleotide binding motifs, named P1-P4, but only PI (AAAI) is able to hydrolyze ATP. 

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