Atlantis

Parc ESTER, 16 rue Atlantis, F-87068 Limoges Cedex, France... 

Clark WM, Wissman S, Albers GW, Jhamandas JH, Madden KP, Hamilton S. Recombinant tissue-type plasminogen activator (Alteplase) for ischemic stroke 3 to 5 hours after symptom onset. The ATLANTIS Study a randomized controlled trial. Alteplase Thrombolysis for Acute Noninterventional Therapy in Ischemic Stroke. JAMA 1999 282 2019-2026 [see comment]. 

Three large randomized trials, the European Cooperative Acute Stroke Study (ECASS) parts I and II, and the Alteplase Thrombolysis for Acute Noninterven-tional Therapy in Ischemic Stroke (ATLANTIS), have investigated the efficacy of IV rt-PA in acute stroke beyond the 3-hour window. All three studies showed high rates of sICH complicating rt-PA treatment, and no overall efficacy of rt-PA. 

The combined experience with IV rt-PA treatment beyond 3 hours, therefore, suggests reduced effectiveness compared to treatment within 3 hours. A pooled analysis of the ATLANTIS, ECASS, and NINDS rt-PA studies confirmed that the odds of a favorable 3-month outcome, defined as minimal or no poststroke disability on the BI, mRS, and NIHSS, decreased with increasing stroke onset to start of treatment time (OTT) (p = 0.005). The odds ratios for favorable outcome with rt-PA treatment were 2.8 (95% Cl 1.8. 5) for OTT 0-90 minutes, 1.6 (95% Cl 1.1-2.2) for 91-180 minutes, 1.4 (95% Cl 1.1-1.9) for 181-270 minutes, and 1.2 (95% Cl 0.9-1.5) for 271-360 minutes. This finding, that earlier treatment is associated with more therapeutic efficacy, supports the adage that in the delivery of acute stroke therapy time is brain. " The rate of sICH was not associated with OTT. ... 

A combined analysis of the ATLANTIS, ECASS-11, and NINDS rt-PA study data found that females had a greater benefit from rt-PA than males (p = 0.04), despite similar initial stroke severity and rates of slCH." This finding may not be relevant to the clinical, FDA-approved use of rt-PA, because most of the analyzed subjects from ATLANTIS and ECASS-11 were randomized greater than 3 hours after stroke onset. Therefore, sex should not be a criterion for patient selection for thrombolysis. 

Hacke W, Donnan G, Fieschi C, Kaste M, von Kummer R, Broderick JR, Brott T, Frankel M, Grotta JC, Haley EC, Jr., Kwiatkowski T, Levine SR, Lewandowski C, Lu M, Lyden R, Marler JR, Patel S, Tilley BC, Albers G, Bluhmki E, Wilhelm M, Hamilton S. Association of outcome with early stroke treatment Pooled analysis of ATLANTIS, ECASS, and NINDS rt-PA stroke trials. Lancet. 2004 363 768-774. 

OR 1.81, 95% Cl 1.46-2.24), most of which were related to symptomatic intracranial hemorrhage (OR 3.37, 95% Cl 2.68. 22). In addition, a pooled analysis of six major randomized placebo-controlled IV rt-PA stroke trials (Alteplase Thrombolysis for Acute Noninterventional Therapy in Ischemic Stroke (ATLANTIS) I and II, European Cooperative Acute Stroke Study (ECASS) I and II, and NINDS I and II), including 2775 patients who were treated with IV rt-PA or placebo within 360 minutes of stroke onset, confirmed the beneht up to 3 hours and suggested a potential beneht beyond 3 hours for some patients. The pattern of a decreasing chance of a favorable 3-month outcome as the time interval from stroke onset to start of treatment increased was consistent with the findings of the original NINDS study. ... 

Bacon, Francis. Francis Bacon s New Atlantis. rhttp //www.levitv.com/alchemy/atl antis, htmll. 

As this work has been claimed as Hermetic, I have classed it as an alchemical text. "The New Atlantis, 1627, is essentially a utopia, in which Bacon outlines an ideal state. It has sometimes been interpreted as an elaborate allegory with hermetic (and even Rosicrucian) undertones. This text was prepared by Kirk Crady from scanner output provided by Internet Wiretap"... 

Bacon, Francis. The New Atlantis. [http //www.alchemvlab.com/bacon.html. 

From Essays, Civil and Moral, and The New Atlantis, by Francis Bacon Areopagitica and Tractate on Education, by John Milton Religio Medici, by Sir Thomas Browne. New York, Collier [cl909] Harvard Classics v. 4. 

Bacon, Francis. New Atlantis / begun by the Lord Verulam and continued by R.H. foreword by Manly P. Hall. Los Angeles (CA) Philosophical Research Soc, 1985. xv,... 

Mythological origins of alchemy, its relationship to Atlantis, Lemuria, and the creation stories in Genesis. 

Stavish, Mark. Alchemy, it s not just for the Middle Ages anymore. Atlantis Rising (Spring 1997). rhttn //www. levitv.com/alchemv/alchemv-middle.htmll. 

In addition, Two tablets not printed previously, Facsimile of original tablet s cover, Map of Atlantis, Three articles on Atlantis by Doreal Secrets of Atlantis, Atlantis and Lemuria, Atlantis and its part in the new age... 

The City of the Sun, by Tommaso Campanella [1568-1639], was originally written in Italian in 1602, just after he was condemned to life imprisonment for sedition and heresy. The original manuscript is in the Bibliotheca Govemativa, Lucca, Tuscany. It was later revised and a Latin version was written in 1613-14. The first printed edition in Latin was issued at Frankfurt in 1623. This is one of the most important utopias, and may have influenced Bacon s New Atlantis. This English version was prepared by Kirk Crady from scanner output provided by Internet Wiretap."... 

Portis, Charles. Masters of Atlantis a novel. Woodstock (NY) Overlook P, 2000. 247p. ISBN 1585670219... 

HILIC Atlantis HILIC 150x2.1 3 lOmM ammonium formate, pH 4.5, 904-8% acetonitrile in 50 min... 

FIGURE 12.5 Human serum tryptic digest analysis. Fractionation in the first LC dimension was performed using a C18 column at pH 10. Fractions were analyzed using NanoEase 0.3 x 150 mm Atlantis d18 column. Approximately 66 lg (400 pmole of semm albumin peptides) was injected on column. Arrow points to a selected albumin peptide illustrating a local column mass overloading. Ten-5mm wide fractions were collected in 1st LC dimension. 

Occult Intersections Atomic Alchemy in Atlantis and the Book of Enoch... 

Moreover, some Hermetic alchemical societies also claimed the sages of Atlantis and Lemuria as a source of their alchemical knowledge.12... 

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