Atherosclerosis arterial injury models

CCR2 deficiency results in decreased atherosclerosis in vessels of susceptible mice. 2. Decreased intimal hyperplasia in femoral artery injury model of atherosclerosis seen with CCR2 deficiency. CCR2 expression is increased in the monocytes of hypercholesterolemic patients. 

Miscellaneous - One of the major problems facing researchers in the atherosclerosis field is the lack of a good laboratory model that resembles the human disease state. Several leads in this area were described during the year. Kramsch and coworkers reported that they Induced severe coronaiy atherosclerosis with 60 6 narrowing of the arterial lumen in all of 40 Macaca Irus monkeys fed a lipid diet for 18 months. The lesions resembled human disease in distribution and microscopic appearance. Similar deposits were also induced in rabbits by homocysteine administration and by allergic injury. ... 

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