Astragalus melanophrurius

Astragalus exilis A. Kor. (Leguminosae) [9]. Astragalus melanophrurius Boiss. (Leguminosae) [10]. 

Recently, cycloartane triterpene glycosides (14-21) from the roots oi Astragalus melanophrurius [57] were shown to stimulate human lymphocyte proliferation in the concentration range of 0.01-10 pg/ml. At higher concentrations (100-200 pg/ml) inhibition of thymidine incorporation was observed. 

Calis I, Yiiriiker A, Tasdemir D, Wright AD, Sticher O, De Luo Y, Pezzuto JM (1997) Cycloartane triterpene glycosides from the roots of Astragalus melanophrurius. Planta Med 63 183-186... 

Taxonomy Cycloartane Glycosides Astragalus tragacantha Habl. (Leguminosae) [1]. Astragalus melanophrurius Boiss. (Leguminosae) [2], Mp 190-195°C (from CHCla-MeOH-HjO, 70 23 4), 0° (c 1.18, MeOH). 

Recently, lymphocyte stimulation tests were performed in order to evaluate the immunomodulatory properties of Astragalus saponins. Lymphocyte proliferation or transformation is a process whereby de novo DNA synthesis takes place in response to a mitogen or any other appreciable stimulator (concanavallin A). Astraversianins II, and X, astragalosides I, II, IV and VI and cyclocantosides E and G isolated from A. melanophrurius were able to stimulate mouse lymphocyte proliferation in the concentration range of 0.01-10 (ig/ml. At higher concentration, inhibition of thymidine incorporation was observed [72]. 

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