Associative substitutions INDEX

Deeb SS, Fajas L, Nemoto M, Pihlaja-maki J, Mykkanen L, Kuusisto J et al. A Prol2Ala substitution in PPARgamma2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity. Nature Genet 1998 20[3] 284—287. 

Deeb, S. S., Fajas, L., Nemoto, M., Pihlajamaki, J., Mykkanen, L., Kuusisto, J., Laakso, M., Fujimoto, W., and Auwerx, J. (1998). A Prol2Ala substitution in PPARy2 Associated with Decreased Receptor Activity, Lower Body Mass Index and Improved Insulin Sensitivity. Nat. Genet. 20, 284-287. 

In the technical library the starting point of all searches is the file of index slips which the library has accumulated. This file includes references in periodicals, government publications, material put out by associations and societies, trade literature, books, literature searches previously made, and miscellaneous material. As in the case of patent searches, an earlier investigation brought up to date may take care of the request or some portion of it. Standard reference works in the field in question are then consulted. Abstract journals are covered next. This step in the search is of the greatest importance, as it serves as a key to the periodical literature. An abstract is not regarded as a substitute for the article abstracted in all but a brief preliminary examination the original reference is read if at all possible. 

Table 10.10c shows the exponents of the Jth independent fluid species, adsorbed species, and surfactant-associated species for the BB(I,)) array. The rows (I index) list the independent and dependent fluid species, adsorbed species on matrix, and surfactant-associated species. In the columns 0 index), the species listed are basically the same as those in the rows (I index) with the exception that the dependent species are not there. The order in which these species are placed in the table is the same as that in the input file, EQIN. Note that the exponents of H for Ca(OH) and OH are -1 because we have to substitute (H for OH to define these two dependent species. 

A more sophisticated approach by Dixon158 derives an index A a large value for A is associated with chemical inertness or preferred substitution over addition. However, at the present time the method has not been applied to heteroaromatics. 

Fujimoto, and]. Auwerx. A Rrol2Ala Substitution in FRARy2 Associated With Decreased Receptor Activity, Lower Body Mass Index and Improved Insulin Sensitivity,... 

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