Assessment of Scoring Functions

Obviously, thorough comparative evaluations are of utmost importance not only for selection and application but also for improvement of scoring functions. Unfortunately practically relevant and truly unbiased comparative assessments are by no means trivial to achieve, as documented by many studies in the recent literature (cf. [156] and references therein). 

Despite all these difficulties and limitations, valuable large-scale assessments of scoring function performance are already available. An instmctive compilation of comparative studies has been presented by Moitessier et al. [167], and further evaluations have appeared since then (e.g., [8, 168-170]). In the following section, we focus primarily on two of the most comprehensive studies at the moment, which have been conducted by Warren et al. [157] and Cheng ef al. [8]. 

Clearly, there is still much need for improvement of scoring functions, and tailored strategies beyond the application of a single score list of a standard scoring function must be recommended for virtual screening applications. 

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R. (2009) Comparative assessment of scoring functions on a diverse test set. Journal of Chemical Information and Modeling, 49, 1079-1093. 

I Clinicians Interview Based Impression of Change (CIBIC) interview-based assessment of global functioning. Score 1 (very much improved) to 7 (very much worse). CIBIC-plus includes interview with carer. Usually a primaiy outcome variable. 

Russell, E.W. A multiple scoring method for assessment of complex memory functions. J Consult Clin Psychol 43 800-809, 1975. Russell, E.W. Renorming the revised Wechsler Memory Scale. Unpublished manuscript, Miami, FL, 1984. 

Population PK screening in Phase II and Phase III is useful in assessing the impact of altered hepatic function (as a covariate) in PKs, if those patients are not excluded from Phase II and III trials, and if there is sufficient PK information collected about the patients to characterize them reasonably well. If a population PK approach is used, patients in Phase II and III studies are assessed for encephalopathy, ascites, serum bilirubin, serum albumin, and prothrombin time (which are components of the Child-Pugh score) or a similar group of measures of hepatic function. The population PK study, then, would include the following features ... 

Functional improvement can be measured using several rating scales, such as a score <70 in the Global Assessment of Function (GAF) Scale (GAF) (DSM-IV American Psychiatric Association, 1994a) or the Children s Global Assessment Scale (C-GAS) (Shaffer et ah, 1983). 

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