Assessment beneficial effect

Unlike systolic HF, few prospective trials have evaluated the safety and efficacy of various cardiac medications in patients with diastolic HF or preserved ejection fraction. The Candesartan in Heart Failure Assessment of Reduction in Mortality and Morbidity (CHARM) study demonstrated that angiotensin receptor blockade with candesartan resulted in beneficial effects on HF morbidity in patients with preserved LVEF similar to those seen in depressed LV function.25... 

Based on the majority of the evidence provided in the scientific database, and despite the limitations, Health Canada and the Canadian Celiac Association (CCA) concluded that the majority of people with celiac disease can tolerate moderate amounts of pure oats. The incorporation of oats into a gluten-free diet provides high fiber and vitamin B content, increased palatability, and beneficial effects on cardiovascular health. However, it is recommended that individuals with celiac disease should have both initial and long-term assessments by a health professional when introducing pure oats into a gluten-free diet. 

Clinical effects In HF patients, digoxin has been proven to reduce symptoms, improve NYHA class, increase exercise time, modestly increase LVEE enhance cardiac output, and decrease HF hospitalizations (56,57). The Randomized Assessment of Digoxin on Inhibitors of the Angiotensin-Converting Enzyme (RADIANCE) (58) and Prospective Randomized study Of Ventricular Failure and the Efficacy of Digoxin (PROVED) (59) trials demonstrated that these beneficial effects are lost when digoxin is withdrawn from the medical therapy. Digoxin withdrawal has been associated... 

Dietary supplementation studies with n-3 fatty acids alone have generally not been promising in atopic dermatitis. An initial double-blind study reported a subjective improvement on fish oil compared with the control OA, but no objective improvement on physician assessment.179 A further double-blind study using EPA with saturated fatty acids as the control, showed equal improvement with both supplements and the benefit was attributed to increased clinician guidance,180 while a multicenter study showed a similar improvement in clinical score in subjects taking fish oil or corn oil.181 The latter results might possibly reflect a beneficial effect of both EFA-containing oils, but more likely imply a placebo effect, and illustrate the problems posed both in selection of a suitable control and the interpretation of such studies. 

The above features make the Smith-Brinkley method valuable for on-line optimization (e.g., using microprocessor or computer control). It can be beneficial for assessing the effects of perturbations on column performance and driving the control point toward an optimum. It is also valuable for off-line optimization and for revamp studies. Rice (58a) extended the Smith-Brinkley method to yield individual stage temperatures and compositions and successfully applied it for control. 

The studies that have shown a beneficial effect of exercise in retarding the development of atherosclerosis in swine and nonhuman primates suggest a beneficial effect in humans. This, of course, awaits confirmation. Of equal importance, as well, is the need for well-controlled investigations to assess the effect of exercise on the reversal of existing atherosclerosis. 

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