Aspects of Organotins in Structural and Molecular Biology

Very recently a family of diphenyltin(IV) compounds was tested in vitro against human tumor cell lines to assess their cytotoxic activity, and the same family of compounds was also tested for antioxidant efficiency in rat brain homogenate, showing that there is a structure-activity relationship in the latter case. The correlation suggests that selected molecular variables are prototype tracers for the calculation of inhibitory concentrations. Moreover there seems to be an inverse structure-response behavior among activities, since the most hydrophobic organotin molecule is the least active compound for cytotoxic assays, while it is the best in anti-oxidant tests. 

The authors acknowledges financial support from CONACYT. N. Farfdn thanks UNAM (PAPIIT fN-203207) and H. I. Beltran SEP-PROMEP (46168-M, 7242/040061) and UAM. 

Gabrielska, M. Soczynska-Kordala, R. ZyUca, and S. Przestalski, Eur. Biophys. J. Biophys. Lett. 34 (2005) 697. 

Ambrosini, E. Bertoli, and G. Zolese, Appl. Organometal. Chem. 10 (1996) 53. 

Chicano, A. Ortiz, J. A. Teruel, and F. J. Aranda, Biochim. Biophys. Acta-Biomembr. 1558 (2002) 70. 

---