Biological Aspects of Organotins Perspectives in Structural and Molecular Biology

6 Biological Aspects of Organotins Perspectives in Structural and Molecular Biology 

Hiram I. Beltrdn, Rosa Santillan and Norberto Farfdn  

2 Interaction of Organotin Compounds with Biological Systems and Mimic Xenobiotics 

An example of the investigation of organotin compounds with deoxyribonucleic acid (DNA), the interaction of two moderately water-soluble anti-tumor organotins, bis[(di-n-butyl-3,6-dioxaheptanoato)tin] 

It has been reported that (CH3CH2CH2CH2)3SnCl exposure in the uterus of rats causes a dramatic increase in low weights of fetuses, due to hypothyroidism in the carrier. Other xenobiotics, such as the RXR agonist bexarotene, have been reported to result in similar symptoms and effects in human patients with lymphoma.  

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