Arteriopathy

Use vasodilator (for treatment of chromic obliterating peripheral arteriopathy and microcircular disorders)... 

Labarrere CA, Nelson DR, Park JW. Pathologic markers of allograft arteriopathy insight into the pathophysiology of cardiac allograft chronic rejection. Curr Opin Cardiol 2001 16 110-117. 

Unlu M et al. Detection of complement factor B in the cerebrospinal fluid of patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy disease using two-dimensional gel electrophoresis and mass spectrometry. Neurosci Lett 2000 282 149-152. 

Missense mutations in the Notch3 gene cause CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and lenkoencephalopathy). Notch is a type I integral membrane protein proteolytically processed in its extracellular domain by fnrin and the metalloproteinase knzbanian. The signal transduction cascade... 

Sauvanier, M., J. Constans, S. Sko-pinski et al. Lower limb occlusive arteriopathy retrospective analysis of 73 patients with onset before the age of 50 years. J Mai Vase 2002 27(2) 69-76. 

Gouny. Cannabis and tobacco cofactors favoring juvenile obliterative arteriopathy. J Mai Vase 2000 25(5) ... 

Iwata, A., Sai, S., Moore, M., Nyhuis, J., de Fries-Hallstrand, R., Quetingco, G.C. et al. (2000) Gene therapy of transplant arteriopathy by hposome-mediated transfection of endothelial nitric oxide synthase. J. Heart Lung Transplant, 19, 1017-1028. 

Lau K-W Sigwart U. Restenosis—an accelerated arteriopathy pathophysiology, preventive strategies and research horizons. In Edelman ER, Levy RJ, eds. Molecular Interventions and Local Drug Delivery. London W. B. Saunders Co. Ltd., 1995 1-28. 

Some congenital diseases such as Marfan syndrome or Ehlers Danlos syndrome (type 4) can cause arteriopathies of cranial cervical vessels. In Ehlers Danlos syndrome, elongations, dissections, dilatation and aneurysms, as well as fistula in large and mid-size arteries, are found. Cystic medial necrosis (Ueda et al. 1999) leads to aortic dissections which can include supraaortic vessels (Fig. 5.27)... 

Van den Boom R, Lesnik Oberstein SA, van Duinen SG, Bor-nebroek M, Ferrari MD, Haan J, van Buchem MA (2002) Subcortical lacunar lesions an MR imaging finding in patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy. Radiology 224 791-796... 

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy... 

Dubroca C, Lacombe P, Domenga V etal. (2005). Impaired vascular mechanotransduction in a transgenic mouse model of CADASIL arteriopathy. Stroke 36 113-117... 

Jung HH, Bassetti C, Tournier-Lasserve E et al. (1995). Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy a clinicopathological... 

Razvi SS M, Davidson R, Bone I et al. (2005). The prevalence of cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy (CADASIL) in the west of Scotland. 

Cerebral microbleeds are seen frequently in patients with primary intracerebral hemorrhage, less commonly in patients with ischemic stroke and rarely in healthy controls (Cordonnier et al. 2007). Risk factors for cerebral microbleeds include hypertension, increasing age, diabetes, cerebral amyloid angiopathy and, less commonly, cerebral autosomal dominant arteriopathy with silent infarcts and leukoaraiosis (CADASIL) (Cordoimier et al. 2007). It is unclear whether previous use of antiplatelet agents or anticoagulants is a risk factor for cerebral microbleeds. 

The main clinical indications for imaging the cerebral circulation are TIA (e.g. to identify arterial stenosis), acute ischemic stroke (e.g. to identify vessel occlusion), intracerebral hemorrhage (e.g. to identify an underlying vascular malformation) and possible arterial dissection, flbromuscular dysplasia or other arteriopathies, cerebral aneurysm, intracranial venous thrombosis or cerebral vasculitis. 

Autosomal dominant arteriopathy (with silent infarcts and leukoaraiosis)... 

Fig. 40.6 Chronic rejection stenosing foamy cell arteriopathy...

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