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Arrestin

Arecaidine propargyl esther, 131 Arecoline, 131, 153 Amdt-Schulz law, 3 B-Arrestin, 84 Assays... [Pg.294]

Lefkowitz RJ, Shenoy SK (2005) Transduction of receptor signals by beta-arrestins. Science 308 512-517... [Pg.49]

Arrestins act as adaptor proteins that bind to phos-phorylated G protein-coupled receptors (GPCR) and link the receptors to clathrin-coated pits. (3-Arrestins are essential in the internalization of many GPCRs. [Pg.222]

Moore CA, Milano SK, Benovic JL (2007) Regulation of receptor trafficking by GRKs and arrestins. Annu Rev Physiol 69 451-482... [Pg.564]

Homologous desensitization is a form of desensitization which is mediated by agonist-induced activation of the same receptor. G-protein-coupled receptor kinases (GRKs) and arrestins are involved in this process, which leads to an uncoupling of the receptor from its G protein. [Pg.599]

Reiter E, Lefkowitz RJ (2006) GRKs and beta-arrestins roles in receptor silencing, trafficking and signaling. Trends Endocrinol Metab 17 159-165... [Pg.1207]

Bohn LM, Gainetdinov RR, Lin FT et al (2000) p-Opioid receptor desensitization by (3-arrestin-2 determines morphine tolerance but not dependence. Nature 408 720-723... [Pg.1207]

Bleich A, Gelkopf M, Weizman T, et al Benzodiazepine abuse in a methadone maintenance treatment clinic in Israel characteristics and a pharmacotherapeutic approach. Isr J Psychiatry Relat Sci 39 104-112, 2002 Bohn LM, Gainetdinov RR, Lin FT, et al Mu-opioid receptor desensitization by beta-arrestin-2 determines morphine tolerance but not dependence. Nature 408 720— 723, 2000... [Pg.96]

Cheng ZJ, Zhao J, Sun Y, Hu W, Wu YL, Cen B, Wu GX, Pei G (2000) Beta-arrestin differentially regulates the chemokine receptor CXCR4-mediated signaling and receptor internalization, and this implicates multiple interaction sites between beta-arrestin and CXCR4. J Biol Chem 275 2479-2485... [Pg.241]

Huttenrauch F, Nitzki A, Lin FT, Honing S, Oppermann M (2002) Beta-arrestin binding to CC chemokine receptor 5 requires multiple C-terminal receptor phosphorylation sites and involves a conserved Asp-Arg-Tyr sequence motif. J Biol Chem 277 30769-30777 Imitola J, Raddassi K, Park KI, Mueller FJ, Nieto M, Teng YD, Frenkel D, Li J, Sidman RL, Walsh CA, Snyder EY, Khoury SJ (2004) Directed migration of neural stem cells to sites of CNS injury by the stromal cell-derived factor lalpha/CXC chemokine receptor 4 pathway. Proc Natl Acad Sci U S A 101 18117-18122... [Pg.244]

Premont RT, Gainetdinov RR (2007) Physiological roles of G protein-coupled receptor kinases and arrestins. Annu Rev Physiol 69 511-534... [Pg.248]

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A arrestin

Arrestin fusions

Arrestin signalling

Arrestins

Arrestins

B-Arrestin

Beta-arrestin

GPCRs arrestin binding

P-Arrestins

Signal 3-arrestin-dependent signaling

Signaling 3-arrestins

Signaling arrestin effects

Signaling arrestin scaffolds

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