Signal 3-arrestin-dependent signaling

Luttrell LM, Gesty-Palmer D (2010) Beyond desensitization physiological relevance of arrestin-dependent signaling. Pharmacol Rev 62 305-330... 

Finally, the atypical chemokine receptors ACKRl—6 (Bachelerie et al., 2014) are able to recruit chemokines and signal via P-arrestin-dependent pathways, but do not couple to G proteins (Graham, Locati, Mantovani, Rot, Thelen, 2012). Thus, scavenger or atypical receptors are firUy biased toward G protein-independent pathways. 

LuttreU, L. M., Gesty-Palmer, D. (2010). Beyond desensitization Physiological relevance of arrestin-dependent signaling. Pharmacological Reuieu/s, 62, 305—330. 

Borroni, E. M., CanceDieri, C., Vacchini, A., Benureau, Y., Lagane, B., Bachelerie, F., et al. (2013). p-arrestin-dependent activation of the cofilin pathway is required for the scavenging activity of the atypical chemokine receptor D6. Science Signaling, 6(273), ra30 31-11, S31-33. 

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