Carcinogenesis, aromatic hydrocarbons

The Bay Region Theory of Polycyclic Aromatic Hydrocarbon Carcinogenesis... 

Polycyclic aromatic hydrocarbon carcinogenesis an introduction. Pages 1-17 in R.D. Harvey (ed.). 

DiGiovanni, J. and T.J. Slaga. 1981b. Modification of polycyclic aromatic hydrocarbon carcinogenesis. Pages 259-292 in H.V. Gelboin and P.O. Ts o (eds.). Polycyclic Hydrocarbons and Cancer. Vol. 3. Academic Press, New York. 

Dipple, A. 1985. Polycyclic aromatic hydrocarbon carcinogenesis an introduction. Pages 1-17 in R.D. Harvey (ed.). Polycyclic Hydrocarbons and Carcinogenesis. ACS Symp. Ser. 283. Amer. Chem. Soc., Washington, D.C. 

Yang, S.K. and Silverman, B.D., Polycyclic Aromatic Hydrocarbon Carcinogenesis Structure-Activity Relationships, CRC Press, Inc., Boca Raton, FL, 1988. 

Cavalieri, E. andRogan, E. Role of radical cations in aromatic hydrocarbon carcinogenesis. Environ. Health Perspect., 64 69-84, 1985. 

Cavalieri, E.L. and Rogan, E.G. (1992) The approach to understanding aromatic hydrocarbon carcinogenesis - the central role of radical cations in metabolic-activation. Pharmacol Then, 55 (2), 183-199. 

P. G. Seybold and K. B. Lipkowitz, Int. J. Quantum Chem., 31, 847 (1987). An Empirical Force Field Examination of the peri Effect in Aromatic Hydrocarbon Carcinogenesis. 

While the molecular size criteria is no doubt important, the carcinogens cannot be discriminated from the noncarcinogens on the basis of size alone. This, again, suggests that polycyclic aromatic hydrocarbons carcinogenesis is a complex process involving many different factors, with molecular size being just one of perhaps many important factors. 

Dipple, A. and Bigger, C.A.H., Mechanism of action of food-associated polycyclic aromatic hydrocarbon carcinogenesis, Mutat. Res., 259, 263, 1990. 

Penn A, Snyder C. 1988. Arteriosclerotic plaque development is promoted by polynuclear aromatic hydrocarbons. Carcinogenesis 9(12) 2185-2189. 

Weibel FJ. 1980. Activation and inactivation of carcinogens by microsomal nonoxooxygenases Modification by benzoflavones and polycyclic aromatic hydrocarbons. Carcinogenesis 5. Modifiers of chemical carcinogenesis. 

DiGiovanni, J., T.J. Slaga, D.L. Berry, and M.R. Juchau Inhibitory effects of environmental chemicals on polycyclic aromatic hydrocarbon carcinogenesis in Carcinogenesis. A comprehensive survey. Vol. 5, edited by T.J. Slaga, Raven Press, New York, NY (1980) 145-168. 

Cavalieri EL, Rogan EG (1985) One-electron oxidation in aromatic hydrocarbon carcinogenesis. In Harvey RG (ed) Polycyclic hydrocarbons and carcinogenesis. Am Chem Soc, Washington DC, pp 289-305... 

This is the second example of the direct observation of an arene oxide during animal liver metabolism of arenes and has provided further evidence that the corresponding epoxides are the key molecules involved in aromatic hydrocarbon carcinogenesis (see also the section on halohydrin cyclization on p. 20). Since the first isolation of a natural product containing an intact epoxide group (1939) a large number of molecules of this type have been isolated. Typical examples recently reported include the coumarins (71) and (72), where the isoprenoid side-chains have been enzymatically epoxidized. The previously isolated Cecrqpia juvenile hormones (73 R = H or Me) have... 

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