Carcinogenesis hydrocarbons

Difluoronaphthalene [315-52-6] is prepared from 4-fluoro-l-naphthylarnine by the Balz-Schiemann reaction. 1,4-Difluoronaphthalene is used in chemical carcinogenesis studies as a synthon for highly condensed difluoro—polycycHc aromatic hydrocarbons (273). 

Epoxides are often encountered in nature, both as intermediates in key biosynthetic pathways and as secondary metabolites. The selective epoxidation of squa-lene, resulting in 2,3-squalene oxide, for example, is the prelude to the remarkable olefin oligomerization cascade that creates the steroid nucleus [7]. Tetrahydrodiols, the ultimate products of metabolism of polycyclic aromatic hydrocarbons, bind to the nucleic acids of mammalian cells and are implicated in carcinogenesis [8], In organic synthesis, epoxides are invaluable building blocks for introduction of diverse functionality into the hydrocarbon backbone in a 1,2-fashion. It is therefore not surprising that chemistry of epoxides has received much attention [9]. 

Harvey R. G. Polycyclic Aromatic Hydrocarbons Chemistry and Carcinogenesis, Cambridge University Press, Cambridge, 1991. 

Conney, A.H. (1982). Induction of Microsomal-Enzymes by Foreign Chemicals and Carcinogenesis by Polycyclic Aromatic-Hydrocarbons—Clowes, G.H.A. Memorial Lecture. Cancer Research 42, 4875 917. 

Polycyclic aromatic hydrocarbons—Physiological effect—Congresses. 2. Polycyclic aromatic hydrocarbons—Congresses. 3. Carcinogenesis— Congresses. 

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