Arndt-Schulz Law

Despite the strong identification of this concept with Schulz, numerous independent researchers such as Jensen commonly observed this dose-response relationship, often without any apparent knowledge that this biphasic dose-response was actually part of a controversial dose response concept of Schulz. Other investigators created a journal called Cell Stimulation based upon the Arndt-Schulz Law/hormesis concept. However, after what appeared to be a very successful initial six years, the publication was ceased in 1930 for reasons that are unclear. 

Despite its experimental failings, medical opposition, linkage to homeopathy, difficulty to prove, and lack of understanding, scientists continued to publish a flow of papers throughout the decades of the twentieth century that were consistent with the hormesis hypothesis. During this first half of the twentieth century the hormesis concept became embodied in the terms Arndt-Schulz Law or Hueppe s Rule. However, in 1943 Chester Southam and John Ehrlich, apparently... 

Adaptive response Biphasic dose response Arndt-Schulz law... 

These observations should not have lead to a refutation of the Arndt-Schulz Law but to a more refined understanding of its temporal features along with its implications for the quantitative features of the dose response. Yet instead of offering such a biological-based refinement that could account for the low dose stimulatory response, leaders in the field rejected the Arndt-Schulz Law and the hormesis concept and the fields of pharmacology, toxicology, and radiation health followed their lead. 

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