Arachidonic acid reactions with nucleophiles

Alternatively reaction of an olefinic alcohol or acid can furnish a dimer through interaction of the bromonium ion with a second molecule of reactant acting as nucleophile. Methoxy bromo adducts are easily made by reaction of the alkene with t-butoxy bromide in methanol solution. Another interesting reaction of this kind is the selective iodination of arachidonic acid and docosahexaenoic acid by iodine and hydrogen peroxide in the presence of lactoperoxidase to give iodolactones. 

Ibuprofen is the generic name for the pain reliever known by the trade names of Motrin and Advil. Like aspirin, ibuprofen acts as an anti-inflammatory agent by blocking the synthesis of prostaglandins from arachidonic acid. One step in a commercial synthesis of ibuprofen involves the reaction of a nucleophilic enolate with an electrophilic carbonyl group. In Chapter 24, we learn about the carbon-carbon bond-forming reactions of enolates with carbonyl electrophiles. 

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