Arachidonic acid prostaglandins

Eicosanoid (Section 27.4) A lipid derived biologically from 5,8.11,14-eicosatetraenoic acid, or arachidonic acid. Prostaglandins, thromboxanes and leukotrienes are examples. [Pg.1240]

Topical corticosteroids (Table 16-1) may halt synthesis and mitosis of DNA in epidermal cells and appear to inhibit phospholipase A, lowering the amounts of arachidonic acid, prostaglandins, and leukotrienes in the skin. These effects, coupled with local vasoconstriction, reduce erythema, pruritus, and scaling. As antipsoriatic agents, they are best used adjunc-tively with a product that specifically functions to normalize epidermal hyperproliferation. [Pg.201]

Aprotic chiral ligands, metal alkyls, 255 Aqueous surfactants, 340 Arachidonic acid, prostaglandin synthesis, 298... [Pg.192]

Bilirubin, estradiol (3-OH), 2-OH-estrone, 2-OH-estradiol trans-retinoic acid, Catechol estrogens (2-OH 4-OH)15-OH-eicosa-tetraenoic acid, 20-OH-eicosa-tetraenoic acid, arachidonic acid, prostaglandin B1... [Pg.124]

OH-estradiol (major), 15-OH-eicosatetraenoic acid, arachidonic acid, prostaglandin B1... [Pg.128]

NSAIDs exert their effects by inhibition of the enzyme cyclo-oxygenase (COX). This results in reduced production of prostaglandins and thromboxanes because COX normally catalyses their formation from arachidonic acid. Prostaglandins play a role in pain by sensitising sensory nerve endings to the effects of other mediators such as bradykinin. [Pg.245]

Bergstrom, S., Danielsson, H. and Samuelsson, B. (1964). The enzymatic formation of prostaglandin E2 from arachidonic acid. Prostaglandins and related factors 32. Biochim. Biophys. Acta, 90, 207-210... [Pg.12]

Rodemann, H.P., and Goldberg, A.L. (1982) Arachidonic Acid, Prostaglandin E2 and F2 Influences Rates of Protein Turnover in Skeletal and Cardiac Muscle, J. Biol. Chem. 257, 1632-1638. [Pg.297]

Prostaglandins are a group of C20 lipids found in all human tissues and fluids. They are derived biosynthetically from all-cis eicosa-5,8,11,14-tetraenoic acid, known commonly as arachidonic acid. Prostaglandin El is an example. Draw arachidonic acid in such a way that it is structurally similar to PGEi in geometry, and identify the two carbons that must form a bond. [Pg.981]

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