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Arachidonate epoxygenase

Certain arachidonate aziridines such as 13-(3-pentyl-2-aziridinyl)-5,8,11-trideca-trienoic acid (104) and its methyl ester (105) have been synthesized [123] which are inhibitors of arachidonate epoxygenase [124]. Preparation of the fatty acid aziridines (106-115) has been described [125]. Bis(aziridine) Me cis-9,10 cw-12,13-diepiminooctadecanoate, derived from hnoleic acid, and tris (aziridine) and Me c /s-9,10 c/s-12,13 cfr-15,16-triepimino-octadecanoate, both derived from linolenic acid, showed cytotoxic and antimicrobial activity as well as remarkable antitumor-promoting and useful neuroprotective effects [126]. [Pg.994]

Arabidopsis thaliana, 1636, 3002, 3584 Arabinose, 2467 Arabinoxylans, 2346 Arachidonate epoxygenase, 994 Arachidonic acid (AA), 3679 2-Arachidonyl glycerol, 3424 Arachis, 1553 Araliaceae, 749 Aralia saponins V, 2952 Araliopsis, 730... [Pg.4167]

Eicosanoid synthesis. Arachidonic acid is converted by cyclooxygenases into prostaglandins, and thromboxanes. Lipoxygenases convert arachidonic acid into HPETEs, which are then converted to lipoxins, leukotrienes, and 12-HETE (hydroxyeicosatetraenoic acid). Epoxygenases convert arachidonic acid into epoxides. [Pg.279]

Alkayed NJ, Narayanan J, Gebremedhin D, Medhora M, Roman RJ, et al. 1996. Molecular characterization of an arachidonic acid epoxygenase in rat brain astrocytes. Stroke... [Pg.80]

Amruthesh SC, Falck JR, EUis EE. 1992. Brain synthesis and cerebrovascular action of epoxygenase metabolites of arachidonic acid. J Neurochem 58 503-510. [Pg.80]

Wu S, Moomaw CR, Tomer KB, Falck JR, Zeldin DC. 1996. Molecular cloning and expression of CYP2J2, a human cytochrome P450 arachidonic acid epoxygenase highly expressed in heart. J Biol Chem 271 3460-3468. [Pg.92]

Zeldin DC, Moomaw CR, Jesse N, Tomer KB, Beetham J, et al. 1996. Biochemical characterization of the human liver cytochrome P450 arachidonic acid epoxygenase pathway. Arch Biochem Biophys 330 87-96. [Pg.92]

Figure 9.5. CYP epoxygenase- and hydroxylase-mediated metabolism of arachidonic acid. Products include biologically active EETs and HETEs. (Adapted from Seubert et al. Prostaglandins and Other Lipid Mediators 82, 50-59, 2007.)... Figure 9.5. CYP epoxygenase- and hydroxylase-mediated metabolism of arachidonic acid. Products include biologically active EETs and HETEs. (Adapted from Seubert et al. Prostaglandins and Other Lipid Mediators 82, 50-59, 2007.)...
Zeldin, D. C. Epoxygenase pathways of arachidonic acid metabolism. /. Biol. Chem. 276, 36059-36062, 2001. [Pg.172]

Chen JK, Capdevila J, Harris RC. Cytochrome p450 epoxygenase 118. metabolism of arachidonic acid inhibits apoptosis. Mol. Cell Biol. 2001 21 6322-6331. [Pg.1780]

P-450 arachidonic acid-derived metabolites have been identified in human urine [189]. The renal cytochrome P-450 system is involved in catalyzing the enzymatic transformation of arachidonic acid. This reaction can involve either an epoxygenase system yielding various epoxides or a mono oxygenase system yielding other oxidation products. Cells of the proximal tubule, thick ascending limb of Henle and the collecting duct contain the major amount of cytochrome P-450 enzyme in the kidney. [Pg.643]

Toto R, Siddhanta A, Manna S, Pramanik B, Faick JR, Capdevila J. Arachidonic acid epoxygenase detection of epoxyeicosatrienoic acids (EETs) in human urine. Biochim Biophys Acta 1987 919 132-139. [Pg.654]

Flolla VR, Makita K, Zaphiropoulos PG, Capdevila JFI. The kidney cytochrome P-450 2C23 arachidonic acid epoxygenase is upregulated during dietary salt loading. J Clin Invest 1999 104 751-760. [Pg.664]

Fig. 1. Cyclooxygenase, lipoxygenase, and epoxygenase pathways leading to the formation of eicosanoids from arachidonic acid. Fig. 1. Cyclooxygenase, lipoxygenase, and epoxygenase pathways leading to the formation of eicosanoids from arachidonic acid.
Fig. 12. Metabolism of arachidonic acid by cytochrome P-450 enzymes and the formation of three structurally distinct metabolite families. Fig. 12. Metabolism of arachidonic acid by cytochrome P-450 enzymes and the formation of three structurally distinct metabolite families. <o-Oxidation leads to a family of to to w-4 products including 20-HETE ((o-oxidation) and 19-HETE (co-1 oxidation). The lipoxygenase-like mechanism of cytochrome P-450 metabolism leads to the formation of six different conjugated dienols, for which the structures of four are indicated. One unique biologically active lipoxygenase-like P-450 metabolite is 12(/f)-HETE. The epoxygenase pathway leads to the formation of four regio-isomeric epoxyeicosatrienoic acid (EETs) all of which are biologically active.
Inhibition of brain P-450 arachidonic acid epoxygenase decreases baseline cerebral blood flow. Am. J. Physiol. 271, H1541-H1546. [Pg.320]

Table 11.2. Effect of Phenobarbital Treatment on the Enantioselectivity of the Liver Microsomal Arachidonic Acid Epoxygenase... Table 11.2. Effect of Phenobarbital Treatment on the Enantioselectivity of the Liver Microsomal Arachidonic Acid Epoxygenase...
Epoxygenase A Member of the Endogenous Arachidonic Acid Metabolic Cascade... [Pg.541]

J.H. Capdevila (1989). Endogenous epoxyeicosatrienoic acids. Cytochrome P-450 controlled stereoselectivity of the hepatic arachidonic acid epoxygenase.Biol. Chem. 264, 19822-19827. [Pg.546]

Keeney, D.S., C. Skinner, S. Wei, T. Friedberg, and M R. Waterman (1998). A keratinocyte-specific epoxygenase, CYP2B12, metabolizes arachidonic acid with unusual selectivity, producing a single major epoxyeicosatrienoic acid. J. Biol. Chem. 273, 9279-9284. [Pg.548]

Capdevila, J.H., S. Wei, Y. Yan, A. Karara, H.R. Jacobson, J.R. Falck et al. (1992). Cytochrome P-450 arachidonic acid epoxygenase. Regulatory control of the renal epoxygenase by dietary salt loading. J. Biol. Chem. 267, 21720-21726. [Pg.548]

F.P. Guengerich, R.N. DuBois et al. (1993). Molecular cloning, expression, and enzymatic characterization of the rat kidney cytochrome P-450 arachidonic acid epoxygenase. J. Biol. Chem. 268, 13565-13570. [Pg.548]

Zeldin, D.C., R.N. DuBois, J.R. Falck, and J.H. Capdevila (1995). Molecular cloning, expression and characterization of an endogenous human cytochrome P450 arachidonic acid epoxygenase isoform. Arch. Biochem. Biophys. 322, 76-86. [Pg.549]

See other pages where Arachidonate epoxygenase is mentioned: [Pg.119]    [Pg.119]    [Pg.187]    [Pg.262]    [Pg.270]    [Pg.435]    [Pg.440]    [Pg.360]    [Pg.362]    [Pg.126]    [Pg.128]    [Pg.128]    [Pg.129]    [Pg.129]    [Pg.157]    [Pg.160]    [Pg.163]    [Pg.167]    [Pg.612]    [Pg.145]    [Pg.332]    [Pg.292]    [Pg.539]    [Pg.548]   
See also in sourсe #XX -- [ Pg.119 ]



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