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Aprotinin cardiopulmonary bypass

Cardiopulmonary bypass, with extracorporeal circulation during cardiac artery bypass graft or heart valve replacement surgery, causes transient hemostatic defects in blood cells and perioperative bleeding. The protease inhibitor aprotinin (Trasylol) inhibits kalhkrein (coagulation phase) and plasmin (hbrinolysis) and protects platelets from mechanical injury. The overall effect after infusion is a decrease in bleeding. [Pg.265]

Barrens RW, Jahr JS. A review of rost-cardiopulmonary bypass bleeding, aminocaproic acid, tranexamic acid, and aprotinin. Am J Ther 1996 3(12) 821-38. [Pg.117]

In a retrospective survey of 200 neonates scheduled for palliative or corrective congenital cardiac surgery requiring cardiopulmonary bypass, 156 were given aprotinin and 44 were not [205 ]. There was more renal dysfunction in those who received aprotinin, although the difference was not statistically significant. Time on bypass and age were significant predictors of postoperative renal dysfunction irrespective of the use of aprotinin. [Pg.726]

Death In a double-blind, randomized, placebo-controlled trial, 298 patients scheduled for low- or intermediate-risk firsttime cardiac surgery with cardiopulmonary bypass were randomized to tranexamic acid, high-dose aprotinin, or placebo. Neither antifibrinolytic agent increased the incidence of death [209 ]. However, a meta-analysis, updated in the light of these data, still showed increased mortality attributable to aprotinin (OR = 1.50 95% Cl = 1.04, 2.27) piO ]. [Pg.726]

Guzzetta NA, Evans FM, Rosenberg ES, Faziollah TM, Baker MJ, Wilson EC, Kaiser AM, Tosone SR, Miller BE. The impact of aprotinin on postoperative renal dysfunction in neonates undergoing cardiopulmonary bypass a retrospective analysis. Anesth Analg 2009 108(2) 448-55. [Pg.738]

Manrique A, Jooste EH, Kuch BA, Lichtenstein SE, Morell V, Munoz R, Ellis D, Davis PJ. The association of renal dysfunction and the use of aprotinin in patients undergoing congenital cardiac surgery requiring cardiopulmonary bypass. Anesth Analg 2009 109(1) 45-52. [Pg.738]


See other pages where Aprotinin cardiopulmonary bypass is mentioned: [Pg.676]    [Pg.676]    [Pg.331]    [Pg.88]    [Pg.414]    [Pg.460]   
See also in sourсe #XX -- [ Pg.726 ]




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