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Aprotic inert solvents

As would be expected, the larger titration potential ranges offer much more scope for mutually distinguishing between individual acids or bases in amphiprotic solvents, as a consequence of self-dissociation, the potential ranges are rather limited, whereas in the aprotic protophilic solvents and "aprotic inert solvents these ranges are considerably more extensive. [Pg.256]

Chichibabin amination refers to a reaction in which a hydrogen of an azaheteroarene is replaced by an amino group. The reaction is usually carried out by heating the heterocycle with a metal amide at elevated temperatures in an aprotic inert solvent. Potassium amide or sodium amide in liquid ammonia have also been found to be appropiate reagents for amination the presence of an oxidant seems to promote the reaction. Potassium nitrate is usually employed as an oxidant, 9 16 but other work shows that potassium permanganate can also successfully be used as an oxidizing agent in liquid ammonia.IO-20 17... [Pg.117]

It is widely held that protic ( acidic ) solvents favour monoalkylation of diethyl malonate carbanion, whereas aprotic ( inert ) solvents favour dialkylation. Exactly opposite results have now been obtained in the reactions of die alkali metal salts of diethyl malonate with 1,2-bis-, 1,2,4,5-tetrakis-, and 1,2,3,4,5,6-hexakis-(bromo-methyl)benzenes in ethanol and in DMSO, the former solvent preferring dialkylation (cyclization) and the latter monoalkylation.106 Other interesting related observations were made. [Pg.316]

Murzina, N.M., A.I. Vokin, S.V. Fedorov et al. 2002. Solvatochromism of heteroaromatic compounds. XVII. Effect of aprotic inert solvents on the structure of 2-(l-methyI-thio-2,2-dicyanovinyI)-5-methyIpyrroIe. 7h Obshch Khim 72 (6) 1011-1014. [Pg.365]

An inert solvent such as benzene, toluene or xylene, or an excess of the alcohol corresponding to the alkoxide is often used as solvent. When a dipolar aprotic solvent such as A,A-dimethylformamide (DMF) or dimethylsulfoxide (DMSO) is used, the reaction often proceeds at higher rate. [Pg.292]

In order to increase our knowledge of the complex electrochemistry in non-aqueous media, we shall consider the phenomena that occur during titrations in solvents with very low e in this connection, it is useful to treat these titrations separately for protogenic and the aprotic solvents, with the latter being subdivided into protophilic and inert solvents. [Pg.274]

This reaction is typical for the synthesis of sulfonylureas it is mildly exothermic and proceeds smoothly in a variety of inert aprotic solvents. The product is usually obtained in very high yield, as a fine crystalline precipitate. The sulfonyl isocyanates are readily prepared from the substituted benzene sulfonamides by reaction with phosgene, Fig. 3, in the presence of an alkyl isocyanate, for example, butyl isocyanate in an inert solvent at 120 to 140°C according to the general procedure of H. Ulrich and A. A. R. Sayigh (Ref. 3). [Pg.22]

Organic solvents can also be classified according to their ability to accept or transfer protons (i.e., their acid-base behavior) [20,21]. Amphiprotic solvents possess donor as well as acceptor capabilities and can undergo autoprotolysis. They can be subdivided into neutral solvents that possess approximately equal donor and acceptor capabilities (water and alcohols), acidic solvents with predominantly proton donor properties (acetic acid, formic acid), and basic solvents with primarily proton acceptor characteristics (formamide, N-methylformamide, and N,N-dimethylformamide). Aprotic solvents are not capable of autoprotolysis but may be able to accept protons (ACN, DMSO, propylene carbonate). Inert solvents (hexane) neither accept nor donate protons nor are they capable of autoprotolysis. [Pg.190]

I11 Section 1.2, some aprotic solvents of low permittivity (Py, THF, diethyl ether, MIBK) were classified as dipolar aprotic solvents, because they have some basicity and behave like polar solvents. Therefore, the solvents considered here are aliphatic or aromatic hydrocarbons and halogenated hydrocarbons that are classified as inert solvents [3, 14]. The solvents of this class interact only very weakly with... [Pg.77]

Therefore, thermodynamics plays a fundamental role in supramolecular chemistry. However, thermodynamics is rigorous and as such, a great deal of ancillary information is required prior to the formulation of an equation representative of the process taking place in solution, such as, the composition of the complex and the nature of the speciation in solution. For the latter and when electrolytes are involved, knowledge of the ion-pair formation of the free and complex salts in the appropriate solvent is required particularly in non-aqueous solvents. This information would allow the establishment of the concentrations at which particular ions are the predominant species in solution. Similar considerations must be taken into account when neutral receptors are involved, given that in dipolar aprotic or inert solvents, monomeric species are not always predominant in solution. In addition, awareness of the scope and limitations of the methodology used for the derivation of thermodynamic data for the complexation process is needed and this aspect has been addressed elsewhere [18]. [Pg.86]

The type of solvent or diluent should be specified in reporting a Ziegler-Natta catalyst system. Alkene polymerisations are usually carried out in inert solvents, such as aliphatic or aromatic hydrocarbons (e.g. some gasoline fractions or toluene). The use of protic or aprotic polar solvents or diluents instead of the hydrocarbon polymerisation medium can drastically alter the reaction mechanism. This usually results in catalyst deactivation for alkene coordination polymerisation. Modern alkene polymerisation processes are carried out in a gas phase, using fluidised-bed catalysts, and in a liquid monomer as in the case of propylene polymerisation [28,37]. [Pg.54]

This article will avoid, as far as possible, duplication of these earlier reports and will emphasize the use of DMSO as an inert solvent in mechanistic investigations of heterolytic reactions. Studies where such use has led to interesting results will of course be highlighted, but others have been selected which illustrate the methods developed for mechanistic study in dipolar aprotic media. Discussion has not been restricted to reactions which give the characteristic rate variations on transfer to dipolar aprotic solvents the effect of DMSO on product distributions is discussed, and we have also speculated on possible future uses of DMSO in mechanistic investigations. [Pg.134]

In this section we shall consider the state of protonic acids in the pure state and in solutions of three classes of solvents (i) amphiprotic-protogenic (mineral and carboxylic acids), (ii) aproticdipolar-protophobic (e.g., acetonitrile and nitromethane), and (iii) aprotic-inert (aliphatic and aromatic hydrocarbons and their haloderivatives). While classes (ii) and (iii) represent the only two families of solvents relevant to cationic polymerisation (with the possible exception of the polymerisation of N-vinylcarbazole, wdiich can be carried out in certain dipolar-protophilic solvents), class (i) is interesting because it represents the interaction between two Br nsted acids, the initiator and the solvent, as a direct source of protonating species. Althou the latter combination has not been used in cationic polymerisation, we will discuss its potentials and possible drawbacks. [Pg.6]

Martin and Fujiwara have shown that the H-F coupling ( H and F n.m.r.) is resolved in solutions of HF in basic solvents, whereas in non-basic solvents it is averaged by exchange. They have therefore proposed that HF forms polymers in inert solvents, but forms 1 1 complexes in basic media. The same workers have also examined FHX ions in aprotic solvents by n.m.r. spectroscopy. " They observed /(H—F) for all four bihalide ions (X = F, Cl, Br, or I). The formation and interconversion equilibria were interpreted by assuming quantitative H transfer to the most basic halide ion in the system. Consistent with this, they showed that the predominant complex in a solution of excess Br in HCl is ClHBr , and not HBrj, as suggested earlier. [Pg.416]

In aprotic solvents. The mechanism of protonation is basically the same as that discussed above. The second order term observed by Bronsted (1928, see above) is due to an equilibrium of the acid catalyst forming dimeric aggregates. Therefore, fastest rates are measured in dipolar aprotic solvents, e.g., dimethyl sulfoxide (Blues et al., 1974). All these kinetic measurements verify a prediction made by Staudinger and Gaule at a very early date (1916), namely, that with acetic acid or trichloroacetic acid in inert solvents the reactivity of substituted diazoalkanes and a-diazo-carbonyl and a,a -dicarbonyl diazo compounds increases as the protonation equilibrium is shifted towards the corresponding alkanediazo-nium ion. This prediction includes the compounds listed in sequence 4-23 ... [Pg.140]

A second type of very useful behavior occurs in aprotic (or sometimes inert ) solvents, which usually exhibit very weak acid properties. Examples are dimethylformamide, dimethylsulfoxide, dioxane, ether, various nitriles, methyl isobutyl ketone, hydrocarbons, carbon tetrachloride. These solvents often permit differentiation (or stepwise titration) of a series of acidic or basic species which, in water, either titrate together or not at all. For example, perchloric, hydrochloric, salicylic, and acetic acids and phenol can be titrated stepwise in methyl isobutyl ketone solvent to obtain discernible endpoints for each compound, using tetrabutyl ammonium hydroxide in isopropyl alcohol as titrant. [Pg.44]

The donor number is frequently used in various fields of polymer chemistry (see Chapter 10). Another classification based on acidity/basicity of solvents allows the division of solvents into six groups containing protic-neutral protogenic protophilic aprotic-protophilic aprotic-protophobic and aprotic-inert. ... [Pg.70]

There is evidence for extensive self-association of phenols, carboxylic acids and certain amines in aprotic solvents at concentrations above 5 X moldm . For example, imidazole at 10 moldm" forms dimers or higher aggregates in inert solvents, and alcohols and... [Pg.126]

We know today that dielectric constant has a lot to do with the effect of a solvent upon spectra. The most nearly inert solvents are the aprotic materials having low dielectric constants. [Pg.271]


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See also in sourсe #XX -- [ Pg.21 ]




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Aprotic

Aprotic solvent

Inert solvents

Solvent aprotic solvents

Solvent inert solvents

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