Applications of Thermal Analysis

These examples will show the reader a typical application of thermal analysis but with common application variations. These variations are useful in defining thermal boundaries within a design. 

Kett, V., McMahon, D., and Ward, K. 2004. Freeze-drying of protein pharmaceuticals - the application of thermal analysis. Cryoletters 25, 389-404. 

Zatka, A. V., "Application of Thermal Analysis in Screening for Chemical Process Hazards," Thermochimica Acta, 28,7 (1979). 

What are some applications of thermal analysis in the pharmaceutical and polymer industries ... 

Application of Thermal Analysis and Photoelectron Spectroscopy for the Characterization of Particulate Matter... 

Aubuchon, S. R., and Blaine, R. L. (1998).Thermal analysis rheology Recent development in the application of thermal analysis to polyolefins. TA Instruments, Inc., New Castle, DE. 

P. Gabhot, (editor), Principles and Applications of Thermal Analysis, John Wiley Sons, New York, 2008. 

The main purpose of this chapter is to review the applications of thermal analysis and calorimetric techniques to the study of catalysts such as oxides, heteropolyanions, hydrotalcites, layered silicates and microporous or mesoporous molecular sieves. A brief summary of studies that made use of calorimetry to characterize crystaUine or amorphous oxides and related materials is also presented. 

Much of the literature on the thermal analysis of polymorphic systems up to 1995 has been cited by Giron (1995), along with many illustrative examples. Perrenot and Widmann (1994), Threlfall (1995), Kuhnert-Brandstatter (1996) and Vippagunta etal. (2001) have also provided excellent discussions of many of the practical aspects of the application of thermal analysis to polymorphic systems. The following discussion draws much from these contributions. 

Application of difiFerential thermal analysis and thermogravimetric analysis techniques to the pyrolysis of cellulose is obviously complicated by the complexity of the reactions involved, and the corrections and simplifying assumptions that are required in calculating the kinetic parameters. Consequently, these methods provide general information, instead of accurate identification and definition of the individual reactions (and their kinetics), which are traditionally conducted under isothermal conditions. The data obtained by dynamic methods are, however, useful for comparing the efiFects of various conditions or treatments on the pyrolysis of cellulose. In this respect, the application of thermal analysis for investigating the effect of salts (and flame retardants in general) on the combustion of cellulosic materials is of special interest and will be discussed later (see p. 467). 

The simplest and most straightforward application of thermal analysis is concerned with studies of the relative stability of polymorphic forms. For example, DTA thermograms enabled the deduction that one commercially available form of chloroquine diphosphate was phase pure, while another consisted of a mixture of two polymorphs. DTA analysis was used to demonstrate that in spite of the fact that different crystal habits of sulfamethazine could be obtained, these in fact consisted of the same anhydrous poly-morph.f In a study aimed at profiling the dissolution behavior of the three polymorphs and five solvates of spironlactone, DTA analysis was used in conjunction with powder X-ray diffraction to establish the character of the various materials. ... 

APPLICATIONS OF THERMAL ANALYSIS TECHNIQUES FOR DRUG SUBSTANCES... 

Brennan, W.P. Some applications of thermal analysis as a supplement to or replacement for ASTM testing standards. Thermochim. Acta 1977,18, 10-13, and 101-111. 

The object of this paper is the application of thermal analysis techniques, such as DTA/TGA, and sintering tests performed in a muffle furnace, in combination with SEM-EDX analysis techniques, to deepen our understanding of the high-teroperattu e of the ash of various solid biofiicls. 

The Application of Thermal Analysis to Pharmaceutical Dosage Forms... 

Gallagher, P. Applications of thermal analysis to the study of inorganic materials. Thermochim. Acta 1993, 214, 1-7. 

Kett V, McMahon D, Ward K. Freeze-drying of protein pharmaceuticals—the application of thermal analysis. Cryo Letters 2004 25(6) 389-404. 

Smith A. Pharmaceutical and biological applications of thermal analysis studies in polymorphism and hydration. Anal Proc 1986 23 338-389. 

Bidstrup, W. Senturia, S. (1987) Society of Plastics Engineers ANTEC 87, pp. 1035-1038. Billingham, N.C., Bott, D.C. Manke, A. S. (1981) Application of thermal analysis methods to oxidation and stabilization of polymers, in Grassie, N. (Ed.) Developments in Polymer Degradation - 3, London Applied Science. 

Charsley, E.L. and Warrington, S.B., Eds., Pharmaceutical applications of thermal analysis, in Thermal Analysis Techniques and Applications, Hardy, M J., Ed., Royal Society of Chemistry, London, 1992, chap. 9. 

Topics include identification of hazardous chemical reactivity, application of thermal analysis to process and reactor design and operation, and management controls. 

Fock. J., Some Applications of Thermal Analysis. Mettler Instrument Corp Griefensee, Switzerland, 1968. 

The main changes in this edition are as follows (1) Numerous new applications of thermal analysis techniques have been added to the chapters on TG, DTA, DSC, EGD/EGA, and others. (2) Other techniques, not used as often, are described in greater detail, such as EGD/EGA, TMA, DMA. thermoptometry, thermoelectrometry, thermosonimetry, and others. (3) The chapter on EGD/EGA has been rewritten, as has the chapter on miscellaneous techniques. (4) The determination of purity by DSC has been rewritten. (5) Commercially available instruments have been briefly described for each technique, including the application of microcomputers to many of these instruments. 

Giron, D. (2002) Applications of thermal analysis and coupled techniques in pharmaceutical industry, J. Therm. Analysis Calorim., 68, 335-357. 

INTRODUCTION TO RECENT ADVANCES, TECHNIQUES AND APPLICATIONS OF THERMAL ANALYSIS AND CALORIMETRY... 

The application of thermal analysis in combination with XRD and FTIR showed that the thermal decomposition of a mixture of barium carbonate and tin tetrahydroxide results in the formation barium staimate that has a cubic perovskite structure and can be used as a sensor for the detection of liquefied petroleum gas [115]. Koferstein and coworkers demonstrated that, starting from... 

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