Application of Estimated Historical Exposure Values to Cancer Risk Estimates

APPLICATION OF ESTIMATED HISTORICAL EXPOSURE VALUES TO CANCER RISK ESTIMATES 

ATSDR makes distinctions regarding different types of dose. It is to use the correct type of dose metric for the scenario of interest. The following terms have been defined by the U.S. ATSDR for use in considaing chemical (nomadiological) exposures or doses (Agency for Toxic Substances and Disease Registry 2005)  

Exposure or Administered Dose. The mathematical estimation of the amount of a substance encountered in Ihe environment per unit of body weight and time. 

Target Tissue Dose. The amount of the absorbed dose reaching the cells or target sites where an adverse effect occurs. 

Biologically Effective Dose. The amount of the target tissue dose needed to produce a biologic response. 

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