Apparent volume of distribution at steady state

Distribution - The plasma protein binding of epierenone is about 50%. The apparent volume of distribution at steady state ranged from 43 to 90 L. Epierenone does not preferentially bind to red blood cells. 

Distribution - Aprepitant is greater than 95% bound to plasma proteins. The mean apparent volume of distribution at steady state (Vdgs) is approximately... 

The apparent volume of distribution at steady state of ertapenem is approximately 8.2 L. 

S Apparent Volume of Distribution at Steady State The volume of distribution that is determined when plasma concentrations are measured at steady state and in equilibrium with the drug concentration in the tissue compartment, VdtSS, is determined as... 

Decitabine (1) exhibits poor oral bioavailability and is consequently administered intravenously. It is rapidly eliminated in animals, with a half-life of 30 minutes in mice, 42 min in rabbits, and 75 min in dogs. For both rabbits and dogs, the apparent volume of distribution at steady state is 800 mL/kg. This is within the range of total body water and consistent with a weak protein-binding drug.12... 

The apparent volume of distribution of ciprofloxacin is 2-3.5 L/kg, and the apparent volume of distribution at steady state is 1.7-2.7 L/kg. Only low concentrations of ciprofloxacin are distributed into cerebrospinal fluid (CSF). Peak CSF concentrations may be 6-10% of peak serum concentrations. The drug is moderately bound to serum protein (16-43%), and crosses the placenta and is produced with the mammary milk [6, 10],... 

The sum of Vi and V2 is termed the apparent volume of distribution at steady state (Vrf(ss)) and is the third distribution volume that we have described. Note also that CLi = k2iVi = ki2V2-... 

Vss, apparent volume of distribution at steady state f p, fraction drug unbound in plasma (C ) , average free (unbound) plasma drug concentration at steady state (Cp) , average total (bound plus free) plasma drug concentration at steady state. ... 

This indicates that the half life is inversely proportional to hepatic clearance (which is unaffected by changes in tissue binding) and directly proportional to the apparent volume of distribution at steady state, which is inversely proportional to the fraction of drug unbound in tissues for drugs with large volumes of distribution. 

The apparent volume of distribution at steady state is a true measure of the extent of a drug s distribution at steady-state equilibrium, since this parameter is independent of any changes in elimination. At any time after steady-state equilibrium has been achieved, it can be viewed as a proportionality constant between mass of drug in the body and plasma drug concentration. 

Apparent Volume of Distribution at Steady State (VdsJ... 

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